Ambrose Mandvulo Dlamini

As the new prime minister, Dlamini announced that he would work on an "economic recovery" plan for the country. In preparation, he cut nonessential government expenses by reusing his predecessor's official vehicle, banning first class air travel for politicians and government employees, and restricting official international travel. The following year, he had to defend the government's decision to suspend cost of living adjustments for public sector employees. In 2020, he published opinion pieces in Business Day and the Financial Mail which outlined plans to develop the economy by improving the country's ease of doing business ranking and supporting economic diversification.

Dlamini had diabetes, and tested positive for COVID-19 during the COVID-19 pandemic in Eswatini on 15 November 2020. He was hospitalized eight days later after developing mild symptoms. He was transferred to a hospital in South Africa in early December, when Deputy Prime Minister Themba N. Masuku said he was in stable condition and responding to treatment. He died there on 13 December at the age of 52, from complications of COVID. He was the first country ruler to die in office from the pandemic. According to the Constitution of Eswatini, Themba Masuku was supposed serve as Acting Prime Minister for a maximum period of three months. Masuku served for nearly seven months, until July 2021 when King Mswati replaced him with Cleopas Dlamini.

Following the death of Prime Minister Barnabas Sibusiso Dlamini in 2018, Dlamini was selected by King Mswati III to succeed him. He was the youngest prime minister in the country's history, and had no prior government experience. His work in government included cutting of nonessential expenses and making plans to improve the country's economy and ease of doing business ranking. He was also the head of the country's AIDS council.

On 27 October 2018, King Mswati III announced in a gathering at the royal kraal at Lobamba that Dlamini would be the country's next prime minister after the 2018 elections; he would succeed Barnabas Sibusiso Dlamini, who died the previous month. At the time, Dlamini had no prior experience in government. He was the youngest head of government in Eswatini's history. The U.S. ambassador Lisa J. Peterson called Dlamini's appointment unconstitutional, as he was not a member of the House of Assembly at the time.

Dlamini worked in the banking sector for more than 18 years, including as managing director of Nedbank from 2003 to 2010. From 2010 to 2018 he was the CEO of the telecommunications company MTN Eswatini, part of the South African MTN Group. In 2017, he approved the company's sponsorship of the MTN SWAMA Awards, a ceremony held by the Eswatini Arts and Music Association (SWAMA).

Ambrose Mandvulo Dlamini (5 March 1968 – 13 December 2020) was a Swazi business executive who served as the tenth prime minister of Eswatini, holding the office from October 2018 until his death on 13 December 2020.

Dlamini was born on 5 March 1968 in Mbekelweni in Eswatini's Manzini Region. His great-grandfather, Prince Malunge, was an uncle to King Sobhuza II. Dlamini was married to Portia Thwala-Dlamini, and they had three children. He graduated from what was then the University of Swaziland and obtained an MBA at Hampton University.