Anders Grubb

Grubb and coworkers isolated a protein previously described to be present in urine and spinal fluid, but without known structure and function, called, among other things, ɣ-trace, and developed a method for measuring it in various body fluids. He also determined the amino acid sequence of the protein's single polypeptide chain and the secondary and 3D-structure of the protein as well as the nucleotide sequence of its mRNA and gene. Northern blot studies showed that cystatin C was produced by all nucleated human cells. The biological function of cystatin C was suggested to be inhibition of cysteine proteinases by Grubb and coworkers in 1984. The role of cystatin C, and peptidyl derivatives mimicking its inhibitory site, in inhibiting the replication of viruses and bacteria was thereafter described, as well as its role in the hereditary disorder Hereditary Cystatin C Amyloid Angiopathy (HCCAA).

Grubb and coworkers discovered in 1979 that cystatin C was a marker of GFR and could be used to estimate GFR. They have used cystatin C for estimation of GFR in the clinical routine since 1994. Grubb and coworkers have developed cystatin C-based GFR-estimating equations, which in several patient cohorts are superior in diagnostic efficiency to creatinine-based GFR-estimating equations, and, in contrast to creatinine-based GFR-estimating equations, do not require controversial coefficients for race or sex. Grubb was chairman of an IFCC working group for development of an international calibrator for cystatin C and such a calibrator, designated ERM-DA471/IFCC, was produced and described in 2010. In a proteomic study, Grubb and coworkers studied the plasma levels of 2893 proteins and found that cystatin C was the one with the highest correlation to measured GFR.

Grubb earned his Ph.D. degree in Clinical Chemistry in 1974 and an M.D. in 1975. Following this, he attended The New York University Medical Center as a Postdoctoral fellow in 1975, and The University Hospital Ramon y Cajal in Madrid in 1980.

Grubb joined the medical faculty of Lund university in 1967. In 1989 he was appointed as Professor and Senior Physician in the Department of Clinical Chemistry and Pharmacology. Since 2011, he has been serving as Senior Professor at the Department of Clinical Chemistry and Pharmacology at Lund University.

Anders Grubb (born 1944) is a Swedish chemist, physician, and academic. He is currently a Senior Professor of Clinical Chemistry at Lund University.