Gordon M. Shepherd

A new appreciation of the human sense of smell suggested a new focus on retronasal smell, which activates an extensive "flavor system" in the human brain; this led in 2015 to a new field of "neurogastronomy", based on his book of that name which has among its goals enhancing understanding of the factors contributing to clinical conditions and global health. A new society and annual meeting have been formed by Shepherd, Dan Han, Frédéric Morin, Charles Spence, Tim McClintock, Bob Perry, Jehangir Mehta, Kelsey Rahenkamp, Siddharth Kapoor, Ouita Michel, and Bret Smith, called the International Society of Neurogastronomy (ISN). ISN is sponsored by the National Institute on Deafness and Other Communication Disorders/National Institutes of Health. The same principles have been applied to wine tasting in Neuroenology These principles are illustrated by animation for Neurogastronomy and Neuroenology.

His lab was among the original group that founded the field of neuroinformatics, with the first funding of the Human Brain Project in 1993. The home site is "SenseLab", which contains a suite of 9 databases supporting research on olfactory receptors, odor maps, neuronal and dendritic properties, and neuronal and microcircuit models. SenseLab was founded by Shepherd, Perry Miller, founder of the Yale Center for Medical Informatics, and Michael Hines, founder of the widely used modeling program NEURON.

The next problem addressed was how odors are represented in the brain. A collaboration in 1975, using new methods of brain imaging, revealed for the first time that odors are encoded by different spatial activity patterns in the olfactory glomeruli of the olfactory bulb. This showed that the neural basis of smell in vertebrates involves odor representation by glomerular activity patterns ("odor images") which are then processed by the widely distributed olfactory bulb microcircuits.

"But probably the tour de force of Rall’s works (and perhaps of computational neuroscience in general) is the 1968 paper of Rall and Shepherd in the Journal of Neurophysiology. Unlike most other Rall studies that provided a conceptual framework, this one is different because it really dived into the guts of a specific system, the olfactory bulb."

His graduate studies in 1963 of the electrophysiology of the olfactory bulb produced one of the first diagrams of a brain microcircuit. Building on this work he collaborated with Wilfrid Rall, just then founding the new field of computational neuroscience, at NIH to construct the first computational models of brain neurons: the mitral and granule cell. This predicted previously unknown dendrodendritic interactions between the mitral and granule cells, subsequently confirmed by electronmicroscopy. These interactions were hypothesized to mediate lateral inhibition in the processing of the sensory input as well as generate oscillatory activity involved in odor processing. The model suggested active properties in the dendrites, which was subsequently confirmed, through which the model accounts for non-topographic interactions throughout the olfactory bulb. This paper was included in the "Essays on APS Classic Papers" series:

Gordon Murray Shepherd (21 July 1933 – 9 June 2022) was an American neuroscientist who carried out basic experimental and computational research on how neurons are organized into microcircuits to carry out the functional operations of the nervous system. Using the olfactory system as a model that spans multiple levels of space, time and disciplines, his studies have ranged from molecular to behavioral, recognized by an annual lecture at Yale University on "integrative neuroscience". At the time of his death, he was professor of neuroscience emeritus at the Yale School of Medicine. He graduated from Iowa State University with a BA, Harvard Medical School with a MD, and the University of Oxford with a DPhill.