Harold M. Weintraub

Weintraub died on March 28, 1995, in Seattle, Washington, as a result of complications from glioblastoma multiforme, a very aggressive and fast-growing brain tumor. He had only been diagnosed six months beforehand, undergoing neurosurgery in an attempt to curb its spread. Weintraub was survived by his wife and two sons. In the years that followed, several items were created in his memory:

Along with chemist Peter Dervan of Caltech and developmental biologist Doug Melton of Harvard, Weintraub was one of three core scientific advisors to Michael L. Riordan, founder of Gilead Sciences, helping to establish the company's scientific vision at its founding during the late 1980s.

In 1978, Weintraub joined the Fred Hutchinson Cancer Research Center (FHCRC), established in 1971 as an independent affiliate of the University of Washington (UW), Seattle. He was a founding member of the Basic Sciences Division, and professor of genetics at UW. As described in an essay by Marc Kirschner, one of his former colleagues at Princeton, "When most of us left [Princeton] in the late 1970s, Hal, typically concerned more with research opportunity than with glamour, went to a young research institution where the practice of science would be paramount." Weintraub remained at "the Hutch" (the nickname for FHCRC) until his death in 1995. In addition, from 1990 to 1995 Weintraub was a Howard Hughes Medical Institute Investigator.

Weintraub spent approximately a year at the Medical Research Council in Cambridge, England, doing a postdoctoral fellowship in the laboratories of Sydney Brenner and Francis Crick. There, his studies of the nucleosome — a basic unit of DNA packaging — showed that its structure was altered when genes were actively transcribed. Weintraub returned to the United States, and between the years 1973–1977 was an assistant professor at Princeton University. His research at Princeton, which would continue during his years in Seattle, applied enzymatic and traditional biochemical isolation/separation techniques to clarify the relationship between the physical structure of genes and their expression (the process by which DNA is transcribed into messenger RNA, and eventually into Protein.) Another avenue of research in Weintraub's lab studied the effects of oncoviruses on cellular gene expression.

Weintraub attended Harvard College, obtaining his bachelor's degree in 1967. He then proceeded to the University of Pennsylvania, where he earned his M.D. and Ph.D. in 1972. Weintraub performed his Ph.D. dissertation research in the laboratory of Howard Holtzer, studying red blood cell development and production (erythropoeisis) in chicken embryos. This work included the study of cell cycle kinetics, hemoglobin synthesis, and the control of cell division. The effects of bromodeoxyuridine on cell differentiation (conversion of a primitive cell into a more specialized cell) were also analyzed. While still only a graduate student, Weintraub's early work contributed significantly to the fields of developmental and cellular biology, yielding numerous peer-reviewed publications and setting the stage for the next chapter in his research explorations.

Harold M. "Hal" Weintraub was an American scientist who lived from 1945 until his death in 1995 from an aggressive brain tumor. Only 49 years old, Weintraub left behind a legacy of research.

Born on June 2, 1945, in Newark, New Jersey, Weintraub's childhood revolved around sports, including basketball, an activity he would continue to particularly relish throughout his adult life. Weintraub was also the pitcher for an all-city high school baseball team, and a football fullback.