Helios Murialdo

At the Department of Molecular Genetics at the University of Toronto, his research advanced the understanding of the morphogenesis and structure of bacterial viruses (bacteriophages). This led to the development of the procedure that later allowed the cloning of human genes. His laboratory was the first to synthesize a complex bacterial virus from its protein components in vitro. His work showed that a specialized structure (the connector or portal) initiates the polymerization of the icosahedral structure of bacterial viruses and provided the first solid evidence that the synthesis of viruses is similar to a crystallization process or a phase transition. His laboratory discovered the first overlapping genes in bacterial viruses, the stimulation of a set of bacterial proteins synthesis upon virus infection, and showed directly, by electron microscopy, that a bacterial protein (IHF) bends DNA. He also worked on the factors that control immunoglobulin gene expression, the structure of the genes and their rearrangement during B-cell differentiation. These experiments led to the discovery of the mutational potential of retrovirus sequences in the mouse genome. Looking back on his life's work, he surmises that his scientific papers will become obsolete and his novels outdated, but that his cellos will improve with time. Just as the best cellos today are those made by the Italian masters Guarneri and Stradivari in the 17th and 18th centuries, he hopes his cellos will continue to make music for the next three hundred years or more.

Helios Murialdo obtained his MSc at the Faculty of Chemistry, University of Chile, in 1965. He became an assistant professor in the Department of Biology, Faculty of Sciences, University of Chile and a lecturer in biochemistry in the Faculty of Agronomical Sciences, at the Catholic University of Chile, in Santiago. He obtained his PhD in molecular biology at the Department of Medical Biophysics, University of Toronto, Canada, in 1971, under the supervision of Dr. Louis Siminovitch. On his return to Chile he was appointed an associate professor in the Faculty of Sciences, University of Chile. From 1973 to 1998 he taught and carried out research in the Department of Molecular Genetics at the University of Toronto, becoming a full professor in 1984. In that year, while teaching a theoretical and laboratory course at the Cuban Center for Genetic Engineering and Biotechnology, he introduced the technique of DNA cloning in Cuba, which led to the establishment of the first sugar cane gene library. He returned to Chile in 1998 and joined Fundación Ciencia & Vida as a research scientist. He retired from active scientific research to write fiction in 2006. During his years as an academic, as a hobby he built cellos admired for their high quality and beautiful sound. He has two daughters from his first marriage to Evelyn Murialdo (née Loewe), former Director of Tenant and Community Services at Toronto Community Housing Corporation. He is now married to the artist Olga Beskoff.