Jim Mellon

In July 2018, Mellon said there would be "a second referendum" that "remain will win".

Mellon donated £100,000 to the Institute of Healthy Ageing at UCL, which allowed them to purchase a structured illumination microscope system. He has also donated in excess of $25,000 to the Methuselah Foundation, which seeks to "help advance the fight against aging". In November 2018, Mellon donated $100,000 to the SENS Research Foundation.

Juvenescence, a biotech company, was founded by Mellon and four others, Greg Bailey, Declan Doogan, Anthony Chow, and Alexander Pickett, in 2016. In 2018, Juvenescence raised $50 million, in a series A financing round. Mellon has invested in longevity medicine company AgeX Therapeutics and other biotechnology companies, via Juvenescence and other investment vehicles.

In March 2016, Mellon said he was less “ideologically committed” to Brexit than his friend Arron Banks, and that there were “good arguments to be made on both sides” of what he saw as a “nuanced” debate.

In November 2016, Mellon felt that "Brexit is going to be a sideshow to the problems of Europe" and predicted that the Euro would not last, saying that "the euro as it stands at the moment is just a very inappropriate mechanism — I give the euro between one and five years of life." He also serves on the executive board of the Initiative for Free Trade, a London-based research foundation founded by another prominent leave-supporter Daniel Hannan MEP, after the Brexit vote, that aims to promote free trade.

He donated up to £100,000 towards campaigns to leave the EU in 2015.

In 2009 Mellon was a leading financial backer of Prime Minister David Cameron and critical of the Labour government's "crazy crackdown on the non-domiciles who bring so much money and expertise into the country".

He is also chairman of Manx Financial Group PLC (the parent company of Conister Bank), of which Brexiteer Arron Banks owns 25%. Banks in 2008, also acquired a "notifiable interest", partly held by his Southern Rock Insurance group, in the gaming company Webis Holdings PLC (watchandwager.com) where Burnbrae holds a controlling stake and Sir James is a non-executive director.

Along with Stephen Dattels, Mellon founded the uranium mining company Uramin in 2005 with just $100,000. Also listed on the stock market in 2006, it sold the following year to Areva for around £1.6 billion, reportedly making him about £80 million. Areva later had to accept a huge write-down in Uramin's value.

Mellon made a donation to Oriel College, a constituent college of the University of Oxford, which was used to construct a purpose-built hall of residence. James Mellon hall was opened by Queen Elizabeth II in November 2000.

Mellon lives on the Isle of Man. In 2000, he was the largest landowner on the Isle of Man. In 2012 he also had homes in Ibiza, Berlin, San Francisco and Brussels. Mellon maintains an interest in thoroughbred horse racing, and owns the racehorse Toffee Galore.

The 1998 Russian financial crisis was disastrous for Regent, with the value of investments in the company's Russian and East European funds becoming almost worthless, and most of its cash tied-up in local currency bonds as the rouble was devalued.

When Regent Pacific acquired a stake in Hambros Bank, Mellon launched a public attack on the board's performance which preceded the break-up of the bank. This and Regent's methods of breaking-up of closed-end funds led to a 1997 Business Week article referring to him and the company's investment director, Peter Everington as "the Bad Boys of Emerging Markets". In 2009 Mellon said "in hindsight I was overly vociferous, and I have not done it again like that — I’m now more behind the scenes".

Along with Jayne Sutcliffe in 1992, he founded Regent Pacific as an emerging markets investment vehicle, with Sir John Templeton their first customer. In 1994 came what Mellon calls his "first really big break". Having read about privatization in Russia he traveled to Vladivostok, and later Moscow, where he found Russians selling vouchers on the streets that could be swapped for stock in Russian industries. In a single day he and Sutcliffe spent $2 million in the covered markets buying the vouchers for about $25 each. A few weeks later the shares were worth $17 million.

A spin-off from Regent Pacific that specialises in Eastern Europe, the fund management firm Charlemagne Capital, was also founded in the 1990s and listed on the stock market in 2006.

After university, in 1979, Mellon went to work as a trainee fund manager at Griffin Thornton (GT Management), spending six months in Hong Kong, before moving to San Francisco. Leaving with Richard Thornton in 1984 to cofound Thornton Management, Mellon returned to Hong Kong to run the company's operation there. Thornton sold for £25 million four years later, making him a millionaire aged 28. He then spent two years setting-up a Hong Kong operation for Tyndall Holdings.

James Mellon (born February 1957) is a British businessman and philanthropist.

James Mellon was born in February 1957 in Edinburgh, Scotland. His father is the former diplomat, Sir James Mellon, who was High Commissioner to Ghana (1978–1983), Ambassador to Denmark (1983–1986) and Consul General in New York (1986–1988). The family are distantly related to the Pittsburgh Mellon banking dynasty.