José Manuel Mireles Valverde

On 25 November 2020, a Mexican government agency confirmed that Mireles had died from "the effects of COVID-19".

On 11 May 2017 after almost 3 years in prison, a federal judge granted Mireles parole after he paid a bond of 30,000 pesos and agreed not to leave the state of Michoacán or the country.

Asav, the main antagonist of the 2017 action adventure game Uncharted: The Lost Legacy was inspired by Mireles. Like him, Asav was also a doctor until he became the leader of a powerful military force.

In 2016, Mireles issued an apology to the government and his family for the disrespect he has shown official institutions in the country. In a video statement posted on social media, he said, "I want to apologize, through this message, to the Mexican government and its official and unofficial institutions, and its nation-wide structures, for disrespecting them with words or actions, for offending them with my omissions and civil disobedience." Charges against him were dropped by the Attorney General; however, Mireles remained in jail.

From prison, Mireles has sent messages to the nation through his former lawyer Talia Vazquez (the current is Javier Livas) and through the Grillonautas YouTube channel. In a message released in 2015, he stated: "Not only Manuel Mireles is innocent, but all self-defense members that had to carry a weapon to defend their home, their family, their property, because there was no one to help them."

Mireles was featured in the 2015 American documentary film Cartel Land.

On 4 January 2014, Mireles was injured in a plane crash as he was traveling to the community of Zicuiran.

In March 2014 some members of the council of Autodefensas distanced themselves from Mireles, stating that he was no longer a member of the leadership nor the official spokesperson of the Autodefensas in Michoacan.

On 27 June 2014, Mireles was arrested with 45 other people in Lázaro Cárdenas, Michoacán by Mexican authorities for violating Mexico's Federal Law of Firearms and Explosives. The government had pledged to arrest civilians who were armed and did not form part of the Fuerza Rural ("Rural Force") police.

He traveled to the U.S. where he worked as a social activist. Upon his return, he started some political work and ran for the Mexican Senate in 2006.

Some media outlets state that in 1988 he served time in prison for allegedly producing marijuana, which Mireles has denied stating his imprisonment was for practicing medicine in Michoacán without an active state license.

José Manuel Mireles Valverde (24 October 1958 – 25 November 2020) was a Mexican medical doctor and leader and founder of the paramilitary self-defense groups that fought against the Knights Templar Cartel, and other cartels, in the state of Michoacán and others, in México. Mireles emerged as an important figure within the self-defense militias during the fall of 2013 as self-defense groups were fighting against the Knights Templar Cartel in Apatzingán and other municipalities on the Michoacán coast. He described his motivation to participate in the armed self-defense groups as stemming from the abuse of the Knights Templar Cartel against himself and his family, himself having been kidnapped by the cartel and several of his family members murdered. This impelled him to take up arms in defense of his community of Tepalcatepec.