P. Roy Vagelos

In 2022, the Vageloses donated $55 million to Barnard College to support the college's STEM education efforts. It is the largest donation in the college's 130-year history.

In 2017, it was announced at the Crown Awards that the College of Physicians and Surgeons would be renamed the Columbia University Roy and Diana Vagelos College of Physicians and Surgeons in recognition of a $250 million gift given by Vagelos to the college. A substantial part of the donation ($150 million) would be used to endow a fund that will help eliminate student loans for medical students who qualify for financial aid. Altogether, the Vageloses have been responsible for about $450 million in philanthropy to Columbia's medical school.

In 2013, Vagelos was invited to speak at the first annual Stony Brook University Research Your Future Symposium.

In 2010, Vagelos, who had earned his medical degree at Columbia University, and Diana, an alumna of Barnard College at Columbia University, donated 50 million dollars to the Columbia College of Physicians and Surgeons, towards the construction of a new building named the Roy and Diana Vagelos Education Center; it opened in August 2016.

He was founding chair of the Prix Galien USA awards committee (from 2007 to 2017) and was the first recipient of the Galien Foundation's Pro Bono Humanum Award, which in 2018 was renamed in his honor to the Roy Vagelos Pro Bono Humanum Award for Global Health Equity.

Since 1995, Vagelos has served as chairman of the board of Regeneron Pharmaceuticals.

In 1995, Vagelos received the NAS Award for Chemistry in Service to Society and was inducted into the Junior Achievement U.S. Business Hall of Fame. In 1999, he became a recipient of both the Bower Award for Business Leadership, as well as the Othmer Gold Medal.

In the mid-1980s, Merck & Co. discovered the drug ivermectin, capable of combatting the parasite that causes river blindness. At the time, the World Health Organization and the World Bank were conducting a campaign against the vector-borne disease in West Africa, and ivermectin was the most important drug in their arsenal. But the newly discovered drug was too expensive for those patients or their governments. Vagelos "wanted to see the drug widely used," so he influenced Merck & Co. to "make needed quantities of the drug available to these governments and patients, at no cost to them, for the treatment of onchocerciasis.” Over two decades, beginning in 1986, the drug reached more than 55 million people. The public health campaign was successful, and now river blindness is no longer a major public health issue in the savannah areas of West Africa.

Vagelos deferred military service while in medical school, but he was obligated to serve a two-year stint as an Army doctor. As a Columbia University College of Physicians and Surgeons trained physician, Vagelos obtained a two-year assignment as a scientist at the National Institutes of Health (1956–1966). For Vagelos, it was a fateful turning point. He was associated with Massachusetts General Hospital, Washington University and the Washington University School of Medicine (1966–1975) before joining Merck, Sharp & Dohme Research Laboratories in Rahway. He was promoted to CEO and Chairman in 1985 and 1986, respectively, succeeding John J. Horan. He retired from Merck in 1994.

Vagelos grew up during the Depression as a son of Greek immigrants. He attended Rahway High School in his hometown of Rahway, New Jersey. After winning a partial scholarship, he left his family's small restaurant in Rahway, to become a doctor. He majored in chemistry at the University of Pennsylvania, graduating Phi Beta Kappa in 1950. Vagelos later earned an M.D. from Columbia University in 1954.

Pindaros Roy Vagelos (born October 8, 1929, in Westfield, New Jersey), better known as P. Roy Vagelos or Roy Vagelos, is an American physician and business executive, who was president and chief executive officer (1985) and chairman (1986) of the American pharmaceutical company Merck & Co. (known as MSD outside the U.S.).