Samantha Mathis

Her 2020 musical, Whisper House, was postponed due to the COVID-19 pandemic.

In 2019, Mathis appeared Off-Broadway in the role of Kate Conlee in Make Believe, a new play by Bess Wohl staged at the Second Stage Theater. Michael Greif directed.

Mathis spoke for the first time publicly about the death of Phoenix in an interview with The Guardian in 2018. She elaborated on the circumstances surrounding Phoenix's death: "I knew something was wrong that night, something I didn’t understand. I didn’t see anyone doing drugs but he was high in a way that made me feel uncomfortable...the heroin that killed him didn’t happen until he was in the Viper Room. I have my suspicions about what was going on, but I didn’t see anything."

Mathis began acting professionally at the age of 16. Her first job was a commercial for "Always Slender Pads – Just For Teens". She co-starred in the television series Aaron's Way and Knightwatch from 1988 to 1989. Her first starring role in a feature film was that of Nora in Pump Up the Volume (1990), opposite Christian Slater, whom she briefly dated at the time. Mathis dyed her natural blonde hair black for the role in an effort to change her image from sweet and innocent to strong-willed.

In 2013, Mathis played psychiatrist Alice Calvert on the CBS television series Under the Dome, based on a novel by Stephen King. In 2014, she joined the cast of the FX horror drama series The Strain as Justine Feraldo, a New York City councilwoman for Staten Island.

Mathis later appeared in American Psycho (2000), a film adaptation of Bret Easton Ellis's 1991 novel of the same name. She starred in Attraction (2000), and in The Simian Line (2001). She starred in the TNT television miniseries The Mists of Avalon (2001). Mathis starred with Thomas Jane in The Punisher (2004). She had a guest role on the ABC television show Lost as Olivia Goodspeed. She played Jane Fonda's daughter in the Broadway show "33 Variations." Her indie film Lebanon, PA had its world premiere at the 2010 SXSW Film Festival. She appeared in an off-Broadway production of the play, Love, Loss, and What I Wore, at New York City's Westside Theatre in October 2011.

Mathis was nominated in 1995 for a Young Artist Award at the Young Artist Awards for Best Young Actress Starring in a Motion Picture for This Is My Life (1992) and in 2005 for a Saturn Award by the Academy of Science Fiction, Fantasy & Horror Films for Best Supporting Actress on Television for Salem's Lot (2004) (TV).

Mathis appeared in the 1994 film adaptation of Little Women, and in How to Make an American Quilt (1995), both starring Winona Ryder. She then appeared in The American President (1995), playing the assistant to the President of the United States. Mathis costarred with Christian Slater again, along with John Travolta, in John Woo's Broken Arrow (1996). She took a little over a year off from acting after her mother died in 1996 from breast cancer.

Mathis met actor River Phoenix on the set of The Thing Called Love (1993) and the two started a relationship. She was with Phoenix on October 31, 1993, the night he died at Cedars-Sinai Hospital of a drug overdose after collapsing outside West Hollywood's Viper Room. She made the film Jack and Sarah (1995), which was shot in London, in order to get out of the country after his death because of the excessive press coverage.

Mathis appeared in the television movies Extreme Close-up, 83 Hours 'til Dawn, and To My Daughter in 1990. Mathis and Slater had voice roles in the animated film FernGully: The Last Rainforest (1992). She next appeared in the comedy This Is My Life (1992), written and directed by Nora Ephron, playing an insecure teenager. Mathis appeared in the play Fortinbras in New York City in October 1992. Super Mario Bros. (1993), in which she played Princess Daisy from the popular Nintendo video game, was a box-office bomb but gained a cult following since its release.

Samantha Mathis (born May 12, 1970) is an American actress and trade union leader who serves as the Vice President, Actors/Performers of SAG-AFTRA. The daughter of actress Bibi Besch, Mathis made her film debut in Pump Up the Volume (1990), and later co-starred or appeared in such films as FernGully: The Last Rainforest (1992), Super Mario Bros. (1993), Little Women (1994), The American President (1995), Broken Arrow (1996), American Psycho (2000), The Punisher (2004), and Atlas Shrugged: Part II (2012). She has recently had recurring roles on The Strain as New York City Councilwoman Justine Feraldo, and on Billions as Taylor Mason Capital COO Sara Hammon.