TotalBiscuit

In mid-April 2018, Bain was hospitalized for extreme back pain, from which the doctors discovered that the cancer was growing, applying pressure on his spine. While he underwent a clinical trial to combat the spread, the doctors found that the cancer had become too resistant to medication and conventional chemotherapy would be ineffective; he was also informed that his liver was failing. The doctors transferred him to palliative care with the option to resume clinical treatment if a trial compatible with his failing liver became available. Because of this, knowing he did not have long left to live, Bain announced he was fully retiring from game criticism, believing he was no longer capable of performing his work at a level that would satisfy himself and his fans. He planned to continue his Co-Optional podcast with his wife Genna, with plans for her to take over the podcast in the event of his death.

On 24 May 2018, Bain's wife Genna announced through both her own and her husband's Twitter accounts that Bain had fallen into a hepatic coma and died. On 9 September 2018, Blizzard Entertainment created a commemorative bundle in honor of Bain, with all sales profits going directly to Genna and their son, Orion.

The main source of Bain's publicity was his primary YouTube channel, where he posted what he described as "variety gaming content" as part of the YouTube gaming network Polaris. His most popular videos belonged to his "WTF is...?" series, a series of first impressions on video games. He was described by Will Porter of Eurogamer as a "champion of indie gaming" and YouTube's foremost "love him or hate him" personality. The same critic suggested Bain's online popularity was due to his voice having a "tone of authority", while Bain himself believed that his candour and personality were key to his success. Prior to his death in May 2018, Bain had over 2.2 million subscribers to his YouTube channel.

In October 2017, Bain appeared on the H3 Podcast, during which he discussed at length the current state of his cancer. He described his condition as "stable" (meaning the cancer was still present, but not spreading), and that it was stage IV cancer. On 22 November, Bain tweeted that his chemotherapy had stopped working, but that there were other types he could try. He also noted that the cancer hadn't spread, but that its growth had started again.

TotalBiscuit was the top Steam curator for several years, with over 800,000 followers at the time of his death. Because of his popularity, Valve, which manages Steam, invited Bain and another gaming critic, Jim Sterling, to their headquarters to help discuss how to improve the Steam's storefront and discovery tools in 2017.

On 3 April 2017, Gearbox Publishing announced a partnership with G2A for exclusive collector's editions of Bulletstorm: Full Clip Edition, to be created and sold by G2A. Bain was critical of this move, citing G2A's negative press coverage as well as accusations made against the company, and threatened to withhold covering Bulletstorm, or any other Gearbox game, unless Gearbox cancelled the deal. On 6 April 2017, one day before Bulletstorm: Full Clip Edition was due for release, Gearbox published a list of ultimatums made together with Bain for G2A to accept, or else it would back out of the deal. The ultimatums focused on G2A's Shield service, an open API for game developers, and G2A's payment system. The following day, Gearbox Publishing publicly announced that it was ending its cooperation with G2A, due to a lack of response from the company concerning the ultimatums. G2A responded to the assertions on 10 April 2017 stating, "All of the requests made of G2A.COM in the ultimatum have in fact long been part of our marketplace", and ascribed the problems to the unfamiliarities that Bain and Gearbox have in regard to how G2A operates its marketplace.

On 23 September 2016, he reported that his cancer had mutated, and a targeted treatment had shrunk his liver tumor by over 50%, from 5 cm (2.0 in) to 2 cm (0.79 in).

In 2016, Twitch added a LUL emoji, sketched from a laughing Bain photo, which has since become one of the most popular emojis on that platform.

Bain reported in April 2015 that a CT scan showed a complete remission of the cancer. However, by October 2015, a newer CT scan showed that while the bowel cancer had been eliminated, the cancer had metastasized to his liver and was determined inoperable, with his doctors giving him a two to three year life expectancy. Bain announced the disbanding of his eSports team Axiom upon this news. By January 2016, Bain had also decided to distance himself from social media, while still focusing on making his game critique videos.

On 15 October 2015, Bain announced the dissolution of Team Axiom because of the return of his cancer and a lack of recent success for the team.

In late April 2014, Bain announced he had a precancerous mass in his colon, the first indications of bowel cancer, a condition with which two of his grandparents had also been diagnosed. Within the month, Bain revealed that he had "full blown cancer" and was beginning chemotherapy treatments.

In July 2014, an online debate about the ethics of YouTube gaming channels was sparked as a result of a survey revealing that some YouTube vloggers received monetary compensation from game developers or publishers in return for recording videos of their games. In response to this discussion, Bain announced on Twitter that he would "be clearly disclosing promotional videos in a splash screen at the start of the video". Disclaimers had previously appeared in the description fields of his videos, but Bain felt this was no longer good enough because YouTube videos that are embedded or that are displayed with certain apps omit that information.

In October 2014, whereas traditional video game review outlets were unable to obtain early access to the video game Middle-Earth: Shadow of Mordor, Bain revealed that YouTube vloggers had been offered early access to the game in exchange for agreeing to a restrictive contract which required them to be positive about it. Federal Trade Commission rules require paid promotional deals on YouTube to be disclosed.

Bain was a runner-up in the Golden Joystick 2012, in category Greatest YouTube Gamer. He has been recognized on several prominent gaming sites including Technorati and Eurogamer. Bain won the 2012 Battle Royale organised by King of the Web and donated his winnings to the non-profit organisation Charity: Water. In 2014, he was an entrant in MCV's Brit List. TotalBiscuit has been nominated for a Shorty Award. On 5 December 2014, Bain received a Fan's Choice The Game Award in the category "Trending Gamer". ESL in 2018 inducted Bain into the Esports Hall of Fame as the first ever non-player.

In October 2013, Wild Games Studio made a copyright claim against Bain's negative "WTF Is... ?" critique of their game Day One: Garry's Incident, which resulted in the video being taken down, despite having issued Bain with a review copy for the game, and use of copyrighted material for criticism being allowed under fair use. Bain's follow-up video responding to the takedown attracted press attention and leveled further criticism against Wild Games Studio, which resulted in the studio retracting its request.

Bain partnered with Sony Online Entertainment for the 2012 E3 event where he hosted a show of attendees playing PlanetSide 2 at Sony Online Entertainment's booth.

Apart from his "WTF is...?" series, Bain hosted the "Content Patch" programme (started from 30 October 2012, ended 15 July 2016) in which he addressed gaming news and comments. Bain also hosted The Game Station Podcast and was a host of the Co-Optional Podcast, where he discussed games and gaming news with YouTube personalities Jesse Cox and Brooke "Dodger" Thorne along with a guest. It was live-streamed every Tuesday on his Twitch channel.

In February 2012, Bain announced that he would be sponsoring Team Dignitas player BlinG, saying: "The StarCraft community has given a lot to me and in turn I've had the opportunity to give back with SHOUTcraft Invitational. Now it is time to take it one step further and directly support a UK talent that I believe has the potential to be one of the best foreigners in the world."

In August 2012, Bain offered to sponsor CranK, formerly a member of team SlayerS, to compete in the MLG Pro Circuit 2012-Summer Championship.

On 26 September 2012, Bain and his wife Genna announced the creation of Team Axiom, with Bain and HuskyStarCraft as the team's sponsors and CranK, now AxCrank, as their first player. The group joined with Team Acer to form the team Axiom-Acer to participate in the GOMTV Global StarCraft II Team League. The Axiom roster consists of AxCrank, AxAlicia, AxHeart and AxRyung.

In 2010 during the height of the Great Recession, Bain was laid off at his job at a financial advisory company. Bain's unemployment coincided with the beta release of World of Warcraft: Cataclysm, and he started producing videos of himself talking over gameplay on YouTube, hoping to earn money through the website's ad-revenue system. In the following weeks, the popularity of Bain's videos skyrocketed. A StarCraft 2 commentator named HuskyStarcraft approached Bain and invited him to The Game Station, a network of gaming channels on YouTube (now Polaris, a subnetwork of Maker Studios).

From 2005 to 2010, Bain ran World of Warcraft Radio, a popular World of Warcraft fan radio station that received special acknowledgment and recognition from Blizzard Entertainment, the developers and publishing team of World of Warcraft. Bain was invited to the annual BlizzCon event in 2005 to provide coverage of the event, where he met Genna Bain, his future wife and fellow YouTube personality. After Bain's tenure at World of Warcraft Radio, Bain began Cynicalbrit.com, where he posted more generalized gaming content.

John Peter Bain (8 July 1984 – 24 May 2018), better known as TotalBiscuit, (or sometimes The Cynical Brit or TotalHalibut) was a British video gaming commentator and game critic on YouTube. He was known for his role in professional shoutcasting and e-sports, and also known for his gaming commentary audio work on WCradio.com. According to Eurogamer, he obtained a large following due to his video commentary on newly developed indie games and analysis of gaming news. Bain voiced strong support for consumer protection in the video gaming industry. In October 2015, Bain announced that he had terminal cancer that had spread to his liver. He continued to critique games after the diagnosis, announcing his retirement only a few weeks ahead of his death in May 2018.