Yuriko, Princess Mikasa

The Prince and Princess had five children, of whom only two are still living. The couple's two daughters left the imperial family upon marriage. All three sons predeceased them. In addition to their five children, they had nine grandchildren and seven great-grandchildren as of 2022.

In July 2022, she was reported to have tested positive for COVID-19 and hospitalized at St. Luke's International Hospital in Tokyo with a slight fever over 37°C and a slight cough, at the age of 99. Her vaccination status was not publicized for reasons of personal privacy.

The princess has used a pacemaker since 1999. In September 2020, the 97-year-old was hospitalized with symptoms of heart failure and pneumonia, but was subsequently released after two weeks. She was notably absent from the 2019 enthronement of Emperor Naruhito. She was admitted to St. Luke's International Hospital in March 2021 due to arrhythmia. It was also announced that her condition was not critical and she was discharged within a few days as her symptoms subsided.

In 1948, the Princess became President of the Imperial Gift Foundation Boshi-Aiiku-kai, a position that she resigned from in September 2010. She has attended several formal occasions in Tokyo as well as other parts of Japan associated with charities concerned with mother and child health issues.

On 29 March 1941, Yuriko's engagement to her second cousin once removed, Takahito, Prince Mikasa, was announced. The engagement ceremony was held on 3 October 1941, and the wedding ceremony took place on 22 October 1941. After her marriage, Yuriko was styled Her Imperial Highness The Princess Mikasa. Princess Mikasa frequently visited her husband who was hospitalized during his final months. On 22 October 2016, they celebrated their 75th wedding anniversary in his hospital room. Prince Mikasa died five days later, with Princess Yuriko at his side. The Princess led her husband's funeral ceremony as the chief mourner.

Yuriko, Princess Mikasa (崇仁親王妃百合子, Takahito Shinnōhi Yuriko) (born Yuriko Takagi (高木百合子, Takagi Yuriko); 4 June 1923), is a member of the Imperial House of Japan as the widow of Takahito, Prince Mikasa, the fourth son of Emperor Taishō and Empress Teimei. The Princess is the last surviving paternal great-aunt-in-law of Emperor Naruhito, and currently is the oldest member of the Imperial Family, and the only living member who was born in the Taishō period.

Princess Mikasa was born on 4 June 1923 at Takagi's family house in Tokyo. She is the second daughter of Viscount Masanari Takagi (1894–1948) and Kuniko Irie (1901–1988). Her father was a member of the Takagi clan, formerly lords of the small feudal domain of Tan'an; through her father, she is a great-great-granddaughter of Hotta Masayoshi, a prominent rōjū, or shōgunal minister, during the Bakumatsu period. Her mother was descended from the noble Yanagihara clan, and was a second cousin of Emperor Shōwa; the Emperor's grandmother, Lady Yanagiwara Naruko, was Kuniko's great-aunt. Yuriko graduated from Gakushuin Women's Academy in 1941.