Dave Mustaine

On June 17, 2019, Mustaine announced that he had been diagnosed with throat cancer.

In November 2017, Mustaine joined the DJ roster for Gimme Radio, promoting his involvement with Megadeth as well as his favorite music and playlists on The Dave Mustaine Show.

However in 2016, Mustaine noted that Lamb of God drummer Chris Adler's comments made him consider playing "The Conjuring" again, "as long as it doesn't hurt anybody".

Mustaine said that he wrote the album Endgame based on conspiracy theorist Alex Jones' film Endgame in order to "educate his fans and the general public about the march towards a New World Order and Global government". In a 2016 Fox Business interview, Mustaine stated that he does not align himself with any established political party, describing himself as an Independent.

Mustaine composed the song "Sudden Death" for the video game Guitar Hero: Warriors of Rock, released in September 2010, under the name of his band. The game also features two additional Megadeth titles, "Holy Wars... The Punishment Due" and "This Day We Fight!". Megadeth downloadable content was available for the game but as of March 31, 2015 the tracks were removed as all DLC for the game was removed; the tracks that were available for purchase were "Symphony of Destruction", "Hangar 18", and "Peace Sells".

Mustaine endorses Seymour Duncan and has his own Signature Live Wire pickups and uses Cleartone strings (.011 – .054 for D tuning, .010 – .052 for E tuning). The Seymour Duncan Dave Mustaine Signature Live Wire pickups were announced at NAMM 2015 and the official product video was performed by Danny Young on the Seymour Duncan YouTube channel.

In November 2011, it was announced the Gigantour would start up again. The lineup consists of Megadeth, Motörhead, Volbeat, and Lacuna Coil. The tour kicked off at the Susquehanna Bank Center in Camden, NJ on January 26, 2012.

In 2012, Mustaine was ranked the 12th greatest guitarist of all time by a Guitar World magazine reader's poll.

In an August 2012 Singapore performance on the tour to support the band's then-new album Thirteen, Mustaine expressed his views of President Obama and recent gun violence in the United States, making an accusation that Obama had staged the shootings at Aurora, Colorado and a Wisconsin Sikh temple in order to push a gun control agenda, while engaging the audience during onstage banter in between songs. Mustaine also criticized the 'Fast and Furious' arms scandal and said that the country looked like it was turning into "Nazi America."

In February 2012, Mustaine gave a statement supportive of the presidential campaign of conservative Republican former United States Senator Rick Santorum. Mustaine commented on Santorum's "presidential qualities." Mustaine pointed to Santorum's temporary suspension of his campaign to be with his sick daughter as the act that gained his attention and respect. He expressed his hope that Santorum would win the nomination but stated that regardless of the results he would be voting against a second term for President Obama. Mustaine also criticized other Republican presidential candidates. Mustaine was critical of a $100 million trust fund that Massachusetts governor Mitt Romney set up for his sons. He criticized Texas Congressman Ron Paul for his unorthodox political views saying Paul "make[s] total sense for a while, and then he'll say something so way out that it negates everything else". Mustaine also admitted that he once supported former Georgia Congressman and House Speaker Newt Gingrich, but that he no longer thought he could vote for him.

On June 16, "The Big Four" thrash metal bands (Megadeth, Metallica, Anthrax, and Slayer) shared the stage in Warsaw, Poland. The event happened in various other countries like Switzerland, the United Kingdom, the United States, Greece, Germany, Sweden and ended at the Yankee Stadium of New York City on September 14, 2011. "The Big Four" show in Sofia, Bulgaria was recorded and released on Blu-ray and DVD.

In 2011, Mustaine said that his neck and spine condition, known as stenosis, was caused by many years of headbanging.

In 2010, longtime bassist David Ellefson rejoined Megadeth eight years after its disbanding in 2002. Ellefson and Mustaine have agreed to keep any unresolved issues in the past and are working on building and maintaining their friendship again. Ellefson has since gone on to say that he feels that "having that time away created a realization for both of us that while we are both productive individually, Megadeth is definitely stronger with both of us in it together." Megadeth embarked on a Rust In Peace 20th-anniversary tour, playing the album in its entirety, along with fan favorites such as "Wake Up Dead", "In My Darkest Hour" and "Skin O' My Teeth".

On August 3, 2010, Mustaine released his autobiography in the US, titled Mustaine: A Heavy Metal Memoir. The book covers Mustaine's life from childhood until the release of the 2009 Megadeth album Endgame. The book was released in the UK, Europe, Australia, and New Zealand under the title Mustaine: A Life in Metal. In December 2011, Mustaine appeared at Metallica's 30th-anniversary celebration at the Fillmore Theater and performed five songs from Metallica's debut album. On October 4, 2014, Mustaine's Alzheimer's-afflicted mother-in-law went missing from a campground. Her remains were discovered on November 26.

The Dean Zero debuted in 2010 with Dean guitars was a unique new shape for Mustaine, resembling the Gibson Explorer with sharper points. Mustaine has made a few appearances so far with this guitar, performing on Late Night with Jimmy Fallon and on shows during the Australian tour with Slayer. He has also used the guitar in the later dates of the 2009 Endgame tour and continues to use it to this day. He says he primarily still uses his VMNT's so he can grab on to the lower horn with his legs for certain songs.

In the 2010s, Mustaine grew increasingly vocal in his support of many Republican figures and positions, which is a change from his politics during the George H. W. Bush administration, when Mustaine acted as a reporter for MTV News during the Democratic National Convention in 1992, and was seen as leaning to the political left, in light of the lyrics of "Foreclosure of a Dream".

In March 2009, while he was guest hosting Bruce Dickinson's Friday night radio show, Mustaine attributed his choice of the Flying V guitar to being a fan of UFO's Michael Schenker when he was growing up.

In 2009, Mustaine was named the No. 1 player in Joel McIver's book The 100 Greatest Metal Guitarists. As he told Classic Rock magazine in September 2009: "It was especially sweet when I found out that Joel has written books on Metallica. Every page I turned, I became more excited. I get to Number 5 and it's Kirk Hammett, and I thought, 'Thank you, God'. At that point it didn't matter [which position I was]. To be better than both of them [James Hetfield and Hammett] meant so much – it's been one of the pet peeves of my career and I've never known how to deal with it. All I thought was – I win!"

The 2008 installment of the tour featured Megadeth, Children of Bodom, In Flames, High on Fire, and Job for a Cowboy (and Evile for the UK and Scandinavia tour).

Megadeth Blood in the Water: Live in San Diego (from the Gigantour 2008) premiered on HDNet Sunday November 2 at 8PM in high definition and 5.1 audio (Repeats check www.hd.net)

The 2007 Gigantour featured Bring Me the Horizon, Static-X, DevilDriver, and Lacuna Coil along with Megadeth. Megadeth appeared on their first tour to Bangalore, India in March 2008.

Mustaine holds black belts in taekwondo and Ukidokan karate. In 2007, he was made a Goodwill Ambassador of the World by the World Taekwondo Federation.

Arsenal of Megadeth, a two-disc anthology DVD, was released on March 21, 2006. Bass player James LoMenzo (Black Label Society, White Lion) replaced James MacDonough in February shortly before the band headed to the Dubai Desert Rock Festival in the United Arab Emirates. On April 19, the band began recording a new album, United Abominations, at SARM studios in the UK (David Gilmour's house), they announced a worldwide deal with Roadrunner Records in May 2006. United Abominations was released worldwide on May 15, 2007. However, the album had already been leaked before its release. On January 13, 2008, Dave Mustaine confirmed that guitarist Glen Drover had quit Megadeth to focus on his family and that he had been replaced by Chris Broderick of Jag Panzer. The new lineup made its live debut in Finland on February 4 and returned to the US for Gigantour 2008 in the spring. The band's twelfth studio album, Endgame, was released on September 15, 2009.

The second annual Gigantour began in September 2006 and was composed of Megadeth, Lamb of God, Opeth, and Arch Enemy. The second stage bands were Overkill, Into Eternity, Sanctity, and the SmashUp.

However, on December 6, 2006, Mustaine announced that he was leaving ESP and shifting his endorsement to Dean Guitars. His new signature guitar was revealed during NAMM Show on January 19, 2007. The signature guitar is called the Dean VMNT. The V-shaped guitar is very similar to his earlier Jackson and ESP Signature models. The release campaign of the VMNT had a limited copy of only 150 in the world and are signed by Mustaine.

The "Blackmail The Universe" tour started in February 2005 with Diamond Head and Dungeon supporting. Capitol released a new greatest hits, Back to the Start, in June, a month before Mustaine created "Gigantour" with Dream Theater, Anthrax, Fear Factory, Symphony X, Dillinger Escape Plan, Life of Agony, and more. During 2005 Gigantour Mustaine brought a "spiritual counselor" to help him avoid the problems that almost cost him his life due to his prior drug addictions. The Dillinger Escape Plan frontman Greg Puciato stated: "He had a pastor walking around with him on tour and riding on his bus, I think to help keep him on the straight and narrow path."

In the summer of 2005, Mustaine launched a travelling North American metal festival. He named it Gigantour after a favorite childhood cartoon of his, Gigantor. It spanned six weeks and was co-headlined by Megadeth and Dream Theater, with a variety of other supporting metal acts such as Fear Factory and the Dillinger Escape Plan. Mustaine has been quoted as saying that his main intention when conceiving the tour was to bring the American metal audiences an eclectic and affordable alternative to Ozzfest.

"After two successful years, I have decided to leave ESP guitars. This was a business decision and had nothing to do with the guitars or the manufacturing of the guitars, and I wish the staff of ESP, both in the USA and in Japan and Korea the very best of health and prosperity. Meanwhile, I am taking my Classic Metal V known formerly as a Jackson King V1 or an ESP DV8, and my new guitar design presently known as an Axxion, which was the recipient of the Gold Award from Guitar World Magazine for 2005 for new guitar designs with me. I will also be re-introducing through my new endorsement many special models, including re-issues of my old models from over the span of my career, as well as some retro V shapes, similar to the formerly known Jackson Y2KV or a Gibson Flying V. I will make my announcement and be attending the 2007 NAMM show to meet Megadeth fans and all metal fans, musicians of all styles-especially guitarists."

In 2004 Mustaine oversaw the remixing and re-mastering of Megadeth's entire Capitol Records catalog. All albums were re-released with bonus tracks and full liner notes. With one album remaining in his contract to Sanctuary Records, Mustaine began recording what he intended to be the first Dave Mustaine solo album with drummer Vinnie Colaiuta and bassist Jimmy Sloas. Complete with guest solos from old friend Chris Poland, this project became a new Megadeth album, The System Has Failed, released on September 14, 2004. One month before, Mustaine announced a new touring lineup for Megadeth: Glen Drover (King Diamond/Eidolon) and James MacDonough (Iced Earth). Nick Menza had briefly been a part of the new band before differences once again caused his departure. One week before a new US tour with Exodus supporting, new drummer (and Glen's brother) Shawn Drover (Eidolon) joined Megadeth.

Mustaine later switched to ESP Guitars. The company released the DV8 signature model in the 2004 NAMM convention also at which time Mustaine announced his ESP endorsement deal. In 2005, Mustaine and ESP teamed up to release the ESP Axxion, (pronounced Action), in order to celebrate Megadeth's 20th anniversary. The ESP Axxion and ESP DV8 were both successful and cheaper models such as the LTD-DV8 R, LTD DV200 and the LTD Axxion were released to target a bigger market.

In 2004, Guitar World magazine ranked Dave Mustaine and Marty Friedman together at No. 19 on the 100 Greatest Heavy Metal Guitarists of All Time.

Mustaine has criticized several Democratic Party politicians. During the 2004 presidential campaign, Mustaine commented that he believed that John Kerry would "ruin our country". In addition, Mustaine has made several comments critical of president Barack Obama, calling him "the most divisive president we've ever had" in 2011, and commenting that he believed that Obama was born outside of the United States during a March 2012 interview on George Stroumboulopoulos Tonight.

Mustaine went through physical therapy for his arm injury. During his recovery, he explored other areas of the music industry, including production. Contrary to what doctors had predicted, within a short time he fully recovered. However, all was mostly quiet on the Megadeth front for the better part of 2003. Mustaine left Jackson guitars, did a solo acoustic performance at a benefit show, unveiled his new ESP model at the NAMM convention, and oversaw the release of Peace Sells... but Who's Buying? as an audio DVD presented in Dolby 5.1 surround sound.

In January 2002, Mustaine was admitted to the hospital to have a kidney stone removed. While undergoing treatment, he was administered pain medication that triggered a relapse. Following his hospital stay, he immediately checked himself into a treatment center in Texas. While at rehab, Mustaine suffered an injury causing severe nerve damage to his left arm. The injury, induced by falling asleep with his left arm over the back of a chair caused compression of the radial nerve. He was diagnosed with radial neuropathy, also known as Saturday Night Palsy, which left him unable to grasp or even make a fist with his left hand.

On April 3, 2002, Mustaine announced in a press release that he was disbanding Megadeth, officially due to his arm injury. For the next four months, Mustaine underwent intense physical therapy five days a week. Slowly, Mustaine began to play again, but was forced to "re-teach" his left hand.

An acoustic tour sponsored by radio stations, a press tour, and a video shoot for the song "Moto Psycho" all preceded the May 2001 release of The World Needs A Hero. The summer was filled with festival appearances supporting AC/DC. In September, Megadeth set out across North America with Endo and Iced Earth. VH1's "Behind the Music" special on Megadeth aired that year and was later released on DVD. At the end of the year, the band filmed two shows in Arizona, which were released as the 2CD and DVD Rude Awakening. The early part of 2002 saw the release of a remixed and re-mastered Killing Is My Business... with bonus tracks and expanded packaging, followed by Rude Awakening.

While touring after Cryptic Writings, Mustaine told interviewers that songs like "She-Wolf" and "Vortex" had reinvigorated his love for classic music by bands like Iron Maiden and Motörhead, and that he intended to write an album that was "1/2 Peace Sells, 1/2 Cryptic Writings"; however, after hearing about a comment that Lars Ulrich had made in the press in which he said he wished Mustaine would take more "risks", intentions changed. Managers and producers had more input. The song "Crush 'Em" was written with the express purpose of being played in wrestling arenas. In later years, Mustaine would blame much of this period on Friedman's desire to go in a more "pop" direction. Recorded with producer Dann Huff, again in Nashville, Risk was released on August 31, 1999. "Crush 'Em" made it onto the Universal Soldier: The Return soundtrack and into WCW wrestling events (notably played live on Monday Nitro). In July, the band covered "Never Say Die" for a second Black Sabbath tribute. They closed the Woodstock '99 music festival and again opened for Iron Maiden in Europe. That year (i.e., 1999) ended with Marty Friedman announcing his departure from the band.

Mustaine's daughter, Electra Mustaine, was born on January 28, 1998, the same month that "Trust" was nominated for a Grammy. Megadeth played on the Howard Stern Show and that summer took part in Ozzfest. As Nick Menza sat in the hospital side-lined by a knee injury, he received a call from Mustaine informing him that his services would no longer be needed. Jimmy DeGrasso, who Mustaine had enjoyed playing with in MD.45, joined Megadeth in his place. On New Year's Eve, Megadeth opened for Black Sabbath alongside Soulfly, Slayer, and Pantera.

Cryptic Writings (1997) included thrashing songs like "Vortex" and "FFF"—reminiscent of Megadeth's older material—alongside radio-friendly fare like "Trust", the song that put Megadeth on the No. 1 spot in the U.S. Billboard, earning them many spins at rock radio. Megadeth.com launched that year, and in June, the reformed Misfits opened for the band on tour. Chaos Comics released "The Cryptic Writings of Megadeth" comic books, and a remix of "Almost Honest" showed up on the "Mortal Kombat Annihilation" soundtrack. The first ever all-acoustic Megadeth performance in Buenos Aires, Argentina closed out the year in December.

A Grammy nomination for "Paranoid" began 1996 for Megadeth. Enlisting Fear singer Lee Ving, Mustaine released an album under the moniker "MD.45" with Suicidal Tendencies drummer Jimmy DeGrasso. In September, Megadeth returned to the studio, this time in Nashville, TN, to record Cryptic Writings.

Another soundtrack appearance, "Diadems" on Tales from the Crypt Presents: Demon Knight, kicked off 1995. Megadeth spent the first two months of the year on the "Youthanasia" tour with Corrosion of Conformity in tow. In March, the Hidden Treasures compilation hit European stores. The "Evolver: The Making of Youthanasia" home video followed in May, and Hidden Treasures made it to the U.S. and Japan in July, just in time for the start of the "Reckoning Day" tour with special guests Flotsam and Jetsam, Korn and Fear Factory. In September the band performed at the "Monsters of Rock" festival in South America, Peru.

Megadeth spent the majority of 1994 making Youthanasia, a much more commercial album undoubtedly inspired in part by the success of Countdown to Extinction. The band covered Black Sabbath's song "Paranoid" for Nativity in Black: A Tribute to Black Sabbath and performed on MTV's "Night of the Living Megadeth" in celebration of the Halloween release of their new album. They began a tour the next month in South America. Youthanasia became the quickest album to go "gold" in Canadian history (i.e. 50,000 units) and sold well throughout the world. It was an album that showed a more melodic side to the band with tracks such as "À Tout le Monde". The album also included "Train of Consequences", the music video for which became one of the band's most well-known.

Pantera and Suicidal Tendencies opened for Megadeth on the Countdown to Extinction tour. MTV News invited Mustaine to cover the Democratic National Convention for them that summer. In November, the "Exposure of a Dream" home video was released. In 1993, Mustaine guested on a new album by one of the bands who had influenced his own sound: Diamond Head. Megadeth began a U.S. tour with Stone Temple Pilots as their opening act. This tour, including a planned appearance at Budokan, was ultimately canceled due to Mustaine's continuing struggles with addiction. In June, Megadeth played Milton Keynes Bowl with Diamond Head and Metallica and later opened for Metallica on a handful of European Stadium dates. Megadeth was kicked off Aerosmith's U.S. tour after just seven dates because a comment made by Mustaine ("We don't have much time to play because Aerosmith don't have much time left to live") was deemed extraordinarily offensive to Aerosmith. "Angry Again" was featured on the soundtrack to the 1993 Arnold Schwarzenegger movie Last Action Hero, while "99 Ways To Die" was featured on The Beavis and Butt-Head Experience compilation album.

Also in 1991, Mustaine collaborated with Sean Harris from Diamond Head on the track "Crown of Worms". Mustaine would later appear on Diamond Head's reformation album Death and Progress. Mustaine's wife, Pamela, gave birth to their son Justis on February 11, 1992. The band was featured on another soundtrack, this time for Super Mario Bros. with the song "Breakpoint". July saw the release of Megadeth's most commercially successful record: Countdown to Extinction. The album debuted at No. 2 on the Billboard 200 and boasted some of the band's most commercially successful songs, including "Symphony of Destruction", "Sweating Bullets" and "Skin o' My Teeth". The original version of the "Symphony of Destruction" video was edited due to its depiction of a political leader being assassinated; "Skin o' My Teeth" was aired on MTV with a disclaimer from Mustaine insisting that the song did not endorse suicide. Ellefson contributed lyrics to the family-farm ballad "Foreclosure of a Dream", and Menza wrote the lyrics about canned hunting for the title track. This album began a new, more "collaborative" Megadeth.

Mustaine married Pamela Anne Casselberry in 1991. They have two children together, Justis David Mustaine (born February 11, 1992) who also plays guitar and has appeared in several local theatrical productions, and Electra Nicole Mustaine (born January 28, 1998), who is attempting a career in country music. As of 2014, they live in Nashville, Tennessee.

Over his career, Mustaine has made numerous comments about both American and international politics, criticizing both politicians and political issues. In addition, Mustaine covered the 1992 Democratic National Convention for MTV.

Megadeth started off 1991 by performing for an audience of 145,000 people at Rock In Rio before starting their own world tour with Alice in Chains as their special guest. Mustaine was married in April, the same month the Rusted Pieces home video was released. That summer, the Clash of the Titans tour hit the U.S., featuring Megadeth, Slayer, and Anthrax, with Alice in Chains taking the opening slot. Later that year, the Megadeth song "Go to Hell" was featured on the soundtrack to Bill & Ted's Bogus Journey.

In February 1990, guitarist Marty Friedman (formerly of Cacophony) was auditioned to fill in the vacant lead-guitar position. In September of that year, the band joined the "Clash of the Titans" tour overseas with Slayer, Suicidal Tendencies and Testament. The tour began one month before Megadeth released Rust in Peace (1990), which was cited as one of the best thrash metal records of all time by publications such as Decibel and Kerrang! and continued their commercial success. They then went back on the road to promote the new album, this time as support for Judas Priest.

Nick Menza, who was Chuck Behler's drum tech, joined Megadeth in 1989, and the band recorded their only track ever as a three-piece: a cover of Alice Cooper's "No More Mr. Nice Guy" for the Wes Craven-directed horror flick, Shocker. Film director Penelope Spheeris would later recount in the Megadeth episode of Behind the Music that Mustaine showed up to the video shoot so fried on heroin and other drugs that he could not sing and play guitar at the same time; therefore, the singing and playing had to be recorded separately. Mustaine was arrested for "impaired driving" that March with seven or more drugs in his system and was forced by authorities to enter a rehabilitation program (the first of his 15 visits to rehabilitation centers).

Chuck Behler, who had been Samuelson's drum tech, became Megadeth's new drummer with guitarist Jeff Young replacing Poland. Megadeth released their third studio album, So Far, So Good... So What!, in January 1988. The album contains the song "In My Darkest Hour", which, according to the liner notes of So Far, So Good... So What!, was composed after the death of Metallica's bass player Cliff Burton, despite the lyrics having nothing to do with Burton. "Hook in Mouth" attacked the Parents Music Resource Center with gusto, although their cover of the Sex Pistols' "Anarchy in the UK", despite a guest appearance from ex-Pistol Steve Jones, was ill-advised in the eyes of Allmusic's critic.

Mustaine was raised as a Jehovah's Witness and is now a born again Christian. In 1988, in response to the British government's Section 28, Mustaine said: "More power to them. It says in the Bible that men should not lay with men like they lay with women. I mean I don't wanna fuck up and not go to heaven." In an answer to a question about Judas Priest having an overt homosexual image, "I don't wanna talk about this. The last thing I need is a bunch of homos picketing us." In 2012, on KIRO-FM he was asked if he supports gay marriage and replied: "Well, since I'm not gay, the answer to that would be no." He was then asked if he would support legislation to make gay marriage legal and said, "I'm Christian. The answer to that would be no."

In a 1988 interview with Sounds journalist Roy Wilkinson, Mustaine spoke against illegal immigration, and stated that he would "build a great wall along the Mexican border and not let anybody in  ..." if he were President of the United States.

In 1988, Mustaine caused a riot when Megadeth played a concert in Northern Ireland after he dedicated a song to "the cause," later claiming surprise that this was a euphemism for supporting the Irish Republican Army (IRA) regarding the problems between Northern Ireland's Catholic and Protestant communities. This incident occurred amidst a period of turmoil in the province known as the Troubles.

In February 1987, Megadeth opened for Alice Cooper on his Constrictor tour. The band also toured with King Diamond whose previous band, Mercyful Fate, were a huge influence on Megadeth. In March, Megadeth's first world tour began in the U.K. Mustaine and Ellefson guested on the band Malice's License To Kill album. Megadeth re-recorded "These Boots" for the soundtrack to the film "Dudes", and that summer went on tour with Overkill and Necros. Amid drug problems and suspicions of stealing the band's equipment and pawning it for drug money, Mustaine fired Poland and Samuelson after their last show in Hawaii.

Mustaine used B.C. Rich guitars early in his career (and for his entire duration with Metallica), most notably a B.C. Rich Bich 10 string with just the regular six strings. First the guitar started in a natural finish, but Mustaine painted it black around the time 'Peace Sells' was released. In 1987, he switched to Jackson Guitars.

In 1986, a year after releasing their debut album, Mustaine approached Jackson Guitars for a custom-built guitar. Jackson modified their existing Jackson King V model for Mustaine by adding 2 more frets to the standard 22 fret King V. In the 1990s the company began mass-producing a Dave Mustaine signature series Jackson King V, which continued into the early 2000s. Production began with the King V Pro, a Japanese-made model, later to be replaced with the American made KV1 and Y2KV models. The King V Pro used a combination of Bill Lawrence and Jackson pickups, while the KV1 and Y2KV used Seymour Duncan SH-4 pickups, also known as TB-4 pickups.

The following year, major label Capitol Records signed Megadeth and obtained the rights to their second studio album, Peace Sells... but Who's Buying?, from Combat. Megadeth opened a U.S. tour with King Diamond and Motörhead. Peace Sells... but Who's Buying?, released on September 19, 1986, is often regarded as a thrash metal classic, producing the notable title track (the opening bass lick of which was used by "MTV News" segments) as well as the thrash anthem "Wake Up Dead". The videos for both songs became staples on MTV's Headbanger's Ball.

In June 1985, Megadeth released their first album, Killing Is My Business... and Business Is Good!, on Combat Records. That summer, the band toured the U.S. and Canada with Exciter. Guitarist Mike Albert replaced Chris Poland when he was incarcerated for possession of heroin. After Poland was released, he rejoined the band in October and the band then began recording their second studio album for Combat. On New Year's Eve of that year, Megadeth played in San Francisco with Exodus and Metal Church. Metallica was the headliner. This was the only time Megadeth and Metallica were on the same card, until 1991.

During his time in Metallica, Mustaine toured with the band, co-wrote four songs that appeared on Kill 'Em All, and co-wrote two songs that eventually appeared on the 1984 album Ride the Lightning. Mustaine has also made unverified claims to have written parts of "Leper Messiah" from Master of Puppets.

After a series of unsuccessful vocalist auditions, Mustaine elected to take on vocal duties himself in addition to playing lead and rhythm guitar. In 1984, Megadeth produced a three-song demo with drummer Lee Rausch, who replaced Carruthers after Mustaine and Ellefson decided they couldn't trust him. Carruthers had chosen to hide his black heritage from them by claiming he was Spanish, and they couldn't understand why he would deceive them since they weren't racist. Kerry King joined the band for a few shows; however, he opted to leave Megadeth after less than a week so he could continue working on his own band, Slayer. Jazz-influenced drummer Gar Samuelson replaced Rausch, who left after Mustaine convinced him to play with a broken foot. Megadeth recorded a demo as a three-piece band, which captured the attention of guitarist Chris Poland, also a jazz player and a friend of Samuelson, who subsequently joined the band. In November, the band signed a deal with Combat Records and began touring.

Metallica began recording their first album titled Kill 'Em All in 1983, but before it was completed, Mustaine's tenure with Metallica was short-lived. Brian Slagel, owner of Metal Blade Records, recalled in an interview: "Dave was an incredibly talented guy but he also had an incredibly large problem with alcohol and drugs. He'd get wasted and become a real crazy person, a raging megalomaniac, and the other guys just couldn't deal with that after a while. I mean, they all drank of course, but Dave drank more… much more. I could see they were beginning to get fed up of seeing Dave drunk out of his mind all the time."

On April 11, 1983, after Metallica had driven to New York to record their debut album, Mustaine was officially fired from the band because of his alcoholism, drug abuse, overly aggressive behavior, and personality clashes with founding members Hetfield and Ulrich, an incident Mustaine refers to as "no warning, no second chance". The band packed up Mustaine's gear, drove him to the Port Authority Bus Terminal, and put him on a Greyhound bus bound for Los Angeles. It was on this bus ride that Mustaine scribbled some lyrical ideas on the back of a hand bill, which later became the song "Set the World Afire" from the 1988 Megadeth album So Far, So Good... So What!

Fallen Angels was the name of the short-lived band that Mustaine founded after his departure from Metallica. In April 1983, after returning to California to live with his mother, he landed what he calls his first real job with the aid of Robbie McKinney. McKinney and a friend, Matt Kisselstein, worked with Mustaine as telemarketers. Mustaine quit his job after earning enough money to move to an apartment in Hollywood, and recruited McKinney, who played guitar, and Kisselstein, who played bass, for his band Fallen Angels. In his biography, Mustaine describes that "We lacked the chemistry, the energy, the spark—or whatever you want to call it—that gives a band life in its infancy." The partnership did not last.

Panic was Mustaine's first band. The lineup was Mike Leftwych on drums, Bob Evans on bass, Tom Quecke on rhythm guitar, Pat Voeks as the vocalist, with Mustaine as the lead guitarist. Both Mike Leftwych and a sound man were killed in a car crash after Panic's second show. Dave stated that after the band started to fall apart in 1981, Quecke also died.

In 1981, Mustaine disbanded Panic and joined Metallica as the lead guitarist. Metallica's drummer Lars Ulrich had posted an ad in a local newspaper, The Recycler, looking for a lead guitarist. In his own words, Mustaine remembers his first meeting with James Hetfield and Lars Ulrich: "I was in the room warming up and I walked out and asked, 'Well, am I gonna audition or what?', and they said, 'No, you've got the job.' I couldn't believe how easy it had been and suggested that we get some beer to celebrate."

David Scott Mustaine (born September 13, 1961) is an American guitarist, singer, songwriter, actor and author. He is best known as the co-founder, lead vocalist, guitarist and primary songwriter of the American heavy metal band Megadeth, as well as the original lead guitarist of the heavy metal band Metallica.

David Scott Mustaine was born September 13, 1961, in La Mesa, California, to Emily (née David) and John Mustaine. His father was of French, German, Irish and Finnish descent, whereas his mother was a German Jewish emigrant. He was brought up as a Jehovah's Witness.

Mustaine has also recently collaborated with Marshall Amplification in order to produce the 1960DM Dave Mustaine Signature Cabinets. He is now using his signature Marshall cabinets on tour.