Francisco J. Quintana

20. Giovannoni F., Bosch I., Polonio M.C., Torti M.F., Wheeler M.A., Li Z., Romorini L., Rodriguez Varela M.S., Rothhammer V., Barroso A., Tjon E. C., Sanmarco L. M., Takenaka M.C, Modaresi S., Gutiérrez-Vázquez C., Ghabdan Zanluqui N., Barreto dos Santos N., Demarchi Munhoz C., Wang Z., Damonte E.B., Sherr D., Gehrke L., Schatzmann Peron J.P., Garcia C.G. and Quintana F.J. AHR is a Zika virus host factor and a candidate target for antiviral therapy. Nature Neuroscience 23, 939-51 (2020).

21. Wheeler MA, Clark IC, Tjon EC, Li Z, Zandee SEJ, Couturier CP, Watson BR, Scalisi G, Alkwai S, Rothhammer V, Rotem A, Heyman JA, Thaploo S, Sanmarco LM, Ragoussis J, Weitz D, Petrecca K, Moffitt JR, Becher B, Antel JP, Prat A, Quintana FJ. Genomic control of astrocytes in multiple sclerosis. Nature. 578, 593-599 (2020).

16. Takenaka M.C., Gabriely G., Rothhammer V., Mascanfroni I.D., Wheeler M.A., Chao C.C., Gutiérrez-Vázquez C., Kenison J., Tjon E.C., Barroso A., Vandeventer T., Alves de Lima K., Rothweiler S., Ghannam S., Zandee S., Healy L., Sherr D., Farez M. F., Pratt A., Antel J., Reardon D.A., Zhang H., Robson S.C., Getz G., Weiner H.L. and Quintana F.J. Control of tumor-associated macrophages and T-cells in glioblastoma via AHR and CD39. Nature Neuroscience 22, 729-740 (2019).

17. Wheeler MA, Jaronen M, Covacu R, Zandee SEJ, Scalisi G, Rothhammer V, Tjon EC, Chao CC, Kenison JE, Blain M, Rao VTS, Hewson P, Barroso A, Gutiérrez-Vázquez C, Prat A, Antel JP, Hauser R and Quintana FJ. Environmental control of astrocyte pathogenic activities in CNS inflammation. Cell 176, 581-596 (2019).

15. Rothhammer V, Borucki DM, Tjon EC, Takenaka MC, Chao CC, Ardura-Fabregat A, de Lima KA, Gutiérrez-Vázquez C, Hewson P, Staszewski O, Blain M, Healy L, Neziraj T, Borio M, Wheeler M, Dragin LL, Laplaud DA, Antel J, Alvarez JI, Prinz M, Quintana FJ. Microglial control of astrocytes in response to microbial metabolites. Nature 557, 724-728 (2018).

13. Yeste, A., Takenaka, M.C., Mascanfroni, I.D., Nadeau, M., Kenison, J.E., Patel, B., Tukpah, A.M., Babon, J.A., DeNicola, M., Kent, S.C., Pozo, D. & Quintana, F.J. Induction of SOCS2 by tolerogenic nanoparticles arrests the diabetogenic T cell response. Science Signaling 9(433):ra61 (2016). Not Federally Funded.

14. Rothhammer V, Mascanfroni ID, Bunse L, Takenaka MC, Kenison J, Mayo L, Chao CC, Patel B, Yan R, Blain M, Alvarez JI, Kébir H, Anandasabapathy N, Izquierdo G, Jung S, Obholzer N, Pochet N, Clish CB, Prinz M, Prat A, Antel J & Quintana FJ. Modulation of astrocyte activity by type I interferon and dietary tryptophan limits inflammation in the central nervous system. Nature Medicine 22, 586-97 (2016).  Not Federally Funded

11. Mascanfroni ID, Takenaka MC., Yeste A, Patel B, Wu Y, Kenison J, Siddiqui S, Basso AS, Otterbein LE, Pardoll DM, Pan F, Priel A, Clish CB, Robson SC, Quintana FJ. Metabolic control of Tr1 cell differentiation by AHR and HIF1-α. Nature Medicine 21, 638-646 (2015).

7. *Quintana, FJ, *Jin, H., Burns, E.J., Nadeau, M., Yeste, A., Kumar, D., Rangachari, M., Zhu, C., Xiao, S., Seavitt, J., Georgopoulos, K., Kuchroo, V.K. Aiolos promotes T(H)17 differentiation by directly silencing Il2 expression. Nature Immunology 13, 770-7 (2012).

4. *Apetoh L., *Quintana FJ, *Pot C., Joller N., Xiao S., Kumar D., Burns E.J., Sherr D.H., Weiner H.L. and Kuchroo V.K. The Aryl hydrocarbon Receptor (AhR) interacts with c-Maf to promote the differentiation of IL-27-induced TR1 cells. Nature Immunology 11, 854- 61 (2010).

5. Gandhi R., Kumar D., Burns E.J., Nadeau M., Dake B., Laroni A., Kozoriz D., Weiner H.L. and Quintana FJ. Aryl hydrocarbon receptor activation induces human Tr1-like and Foxp3 Treg cells. Nature Immunology 11, 846-53 (2010).

3. *Farez, M.F., *Quintana F.J., Gandhi, R., Izquierdo, G., Lucas, M. & Weiner, H.L. TLR2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE. Nature Immunology 10, 958-964 (2009).  Corresponding author.

2. Quintana, FJ, Basso, A.S., Iglesias, A.H., Korn, T., Farez, M.F., Bettelli, E., Caccamo, M., Oukka, M. & Weiner, H.L. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 453, 65-71 (2008).

Dr. Quintana received his Diploma in Biology from the University of Buenos Aires. He received his PhD in Immunology from the Weizmann Institute of Science in 2004, where he was advised by Dr. Irun Cohen. Dr. Quintana joined Brigham and Women's Hospital and Harvard Medical School as a postdoctoral fellow in 2005 where he was advised by Dr. Howard L. Weiner. In 2018, Dr. Quintana was appointed Professor of Neurology with tenure. Dr. Quintana is also an Associate Member of the Broad Institute of MIT and Harvard. Dr. Quintana is the president of International Society of Neuroimmunology (2021–2023).

Dr. Quintana has received multiple awards including the Lady Anne Chain Prize for Academic and Scientific Achievements (2004), the Junior Investigator Award from the National MS Society for Outstanding Research (2008), the NIH Pathway to Independence Award (2009), the Nature Publications Award for Outstanding Research Achievements (2009), the Harry Weaver Research Scholar Award (2014), the Harvard Medical School Young Mentor Award (2016), the Milestone in MS Research Award (2017), the American Association of Immunologists-BD Biosciences Investigator Award (2019), ISI Most Highly Cited List since 2019, and the Barancik Prize for Innovation in MS Research (2020). Dr. Quintana is the Indirawati Kuchroo and Charlotte Weiner Distinguished Professor of Neuroimmunology (2021).

Francisco J. Quintana (born April 30, 1974) is an Argentinean-American immunologist and neuroscientist, and Professor of Neurology at Harvard Medical School. His lab studies interactions between the immune system and nervous system. He is best known for his work on the regulation of inflammation by astrocytes, and by the study of the role of the Aryl Hydrocarbon Receptor in the regulation of the immune response by pollutants, the microbial flora and metabolism. Dr. Quintana's research has implications for our understanding of the pathology of multiple inflammatory disorders including multiple sclerosis, Type 1 diabetes and Inflammatory Bowel Disease, and also brain tumors and infectious diseases. His work has also led to the development of novel therapeutic interventions.