Jean Weigle

In 1952, Salvador Luria had discovered the phenomenon of "restriction modification" (the modification of phage growing within an infected bacterium, so that upon their release and re-infection of a related bacterium the phage's growth is restricted), (also described in Luria's autobiography, pgs. 45 and 99). Work by Jean Weigle and Giuseppe Bertani at almost the same time, and later work by others clarified the basis for this phenomenon. They showed that restriction was actually due to attack by specific bacterial enzymes on the modified phage's DNA. This work led to the discovery of the class of enzymes now known as "restriction enzymes." These enzymes allowed controlled manipulation of DNA in the laboratory, thus providing the foundation for the development of genetic engineering.

After suffering his first heart attack in 1946 he emigrated to the US in 1948, resigned from the faculty of the University of Geneva and went to Caltech in Pasadena, California. There he turned to biology and worked in the Phage group of Max Delbrück, Seymour Benzer, Elie Wollman, and Gunther Stent. While at Caltech, Weigle worked with other notable molecular biologists, including George Streisinger (whom Weigle mentored as a postdoctoral researcher), Giuseppe Bertani, and Nobel laureate Werner Arber.

Jean Weigle was born in Geneva, Switzerland, where he obtained his PhD in physics in 1923, from the University of Geneva. He married Ruth Juliette Falk, a widow. He died in Pasadena, California, after suffering a heart attack in 1968.

As a physicist he was awarded for his research on x-ray diffraction to the study of crystal structure; the effects of temperature on this diffraction; the diffraction of light by ultrasonics. He was working as professor of Physics at the University of Pittsburgh in the 1920s. At the University of Geneva he became director of the Institute of Physics in 1931. He developed the first electron microscope made in Switzerland, an important factor for the studies of molecular biology leading to creation in 1964 of the Institute of Molecular Biology (MOLBIO) in Geneva by Eduard Kellenberger and others.

Jean-Jacques Weigle (9 July 1901 – 28 December 1968) was a Swiss molecular biologist at Caltech and formerly a physicist at the University of Geneva from 1931 to 1948. He is known for his major contributions on field of bacteriophage λ research, focused on the interactions between those viruses and their E. coli hosts.