John Buster

In January, 2020, Buster with the Previvo research team reported the first large series (134 hyper stimulation/lavage cycles) describing the successful and safe recovery of 136 in vivo fertilized and matured embryos using in vivo uterine lavage (IVL). For controls, 20 of the lavage subjects also underwent in vitro fertilization (IVF). Most significantly the morphology scores of the IVL blastocysts were significantly higher than the IVF controls.

In April 2019 at the International Federation of Fertility Societies (IFFS)World Congress in Shanghai, China, Buster presented the preliminary results from the first Preimplantation Genetic Testing (PGT) using in vivo Embryos recovered by Uterine Lavage.

In June 2014 the American College of Obstetricians and Gynecologists (ACOG) awarded a permanently endowed lectureship, the John E. Buster, M.D. lectureship on cutting edge reproductive medicine. This lecture is given annually.

Buster received the Legends Award in May 2012 from LA BioMed located at Harbor-UCLA Medical Center.

Buster updated the uterine lavage technology adapting it to diagnosis and prevention of genetic diseases in embryos. In 2011 Buster founded Previvo Genetics, Inc. He serves on the Board of Directors and Scientific Board.

Buster helped develop a testosterone delivery system for women researched by Procter & Gamble. It is marketed in Europe under the brand name Intrinsa. Buster served as lead investigator in another study demonstrating the effectiveness of an estradiol mist, which has pharmacology similar to those of a trans-dermal estrogen patches. Sold in the United States by Perrigo under the name Evamist, it received FDA approval in 2007. Buster's Phase III Study for Evamist was published in the journal, Obstetrics & Gynecology.

In the early 1980s, over a period of 4 years, at the University of California at Los Angeles School of Medicine, Buster and his team developed a technique based on in vivo fertilization and uterine lavage – a method adapted from the commercialization of bovine embryo transfer in the cattle industry – as a means to transfer human blastocysts from fertile woman donors to ovulating or agonadal infertile recipient women. In February 1984, the first live birth, followed 3 months later by a second live birth, resulted from these techniques and was reported by Buster and his team.

John Edmond Buster (born July 18, 1941) is an American physician who, while working at the University of California at Los Angeles School of Medicine, directed the research team that performed the first embryo transfer from one woman to another resulting in a live birth. It was performed at the Harbor-UCLA Medical Center, reported in July 1983, and culminated in the announcement of the birth on February 3, 1984. In the procedure, an embryo that was just beginning to develop was transferred from the woman in whom it had been conceived by artificial insemination to another woman who gave birth to the infant 38 weeks later. The sperm used in the artificial insemination came from the husband of the woman who bore the baby.