Maysoon Zayid

Zayid has said repeatedly that she wants to appear on the ABC daytime soap opera General Hospital, and in June 2019 she debuted in the recurring role of Zahra Amir in the series.

In June 2016 it was announced that Zayid would be developing a series about her life with Lindsey Beer.

Zayid can be seen in the 2013 documentary The Muslims Are Coming!, which features a group of Muslim American stand up comedians touring the United States in an effort to counter Islamophobia, as well as various celebrities including Jon Stewart, David Cross, Janeane Garofalo and  Rachel Maddow. In December that same year she appeared on the Melissa Harris-Perry show on December 30, 2013 as part of a panel of comedian commentators. She has also presented at the TED annual conference, and her TED Talk has been viewed approximately 1 billion times.

Zayid had a role in the 2008 Adam Sandler film, You Don't Mess with the Zohan.

In late 2006, Zayid debuted her one-woman show Little American Whore (LAW) at Los Angeles's Comedy Central stage; it was produced and directed by Kathy Najimy. In 2008, LAW's screenplay was chosen for the Sundance Screenwriters Lab. Production began with Zayid as the lead in the fall of 2009.

She co-founded the New York Arab-American Comedy Festival in 2003 with comedian Dean Obeidallah. It is held annually in New York City and showcases Arab-American comics, actors, playwrights and filmmakers.

Zayid was born in New Jersey in 1974. She described herself in a BBC interview as "a Palestinian Muslim virgin with cerebral palsy, from New Jersey, who is an actress, comedian and activist". Zayid has been a resident of Cliffside Park, New Jersey. Zayid earned her BFA in acting from Arizona State University.