Princess Mabel of Orange-Nassau

In 2015 she signed an open letter which the ONE Campaign had been collecting signatures for; the letter was addressed to Angela Merkel and Nkosazana Dlamini-Zuma, urging them to focus on women as they serve as the head of the G7 in Germany and the AU in South Africa respectively, which will start to set the priorities in development funding before a main UN summit in September 2015 that will establish new development goals for the generation.

In May 2012, Mabel van Oranje resigned as CEO of The Elders, following the February 2012 accident in which her husband, Prince Friso, was caught in an avalanche and remained hospitalised until his death on 12 August 2013. She continues to be involved with The Elders as a member of its Advisory Council, which she sits on in her capacity as Advisory Committee Chair of Girls Not Brides: The Global Partnership to End Child Marriage.

Because he did not ask the Dutch parliament for permission to marry, Prince Friso ceased being a member of the royal house and forfeited his and his future children's succession rights. Therefore, neither Princess Mabel nor their daughters are members of the royal house. Prince Friso died in 2013.

From July 2008 till May 2012 she was the first Chief Executive Officer of The Elders, a group of eminent individuals convened by Nelson Mandela to use their wisdom, independent leadership and experience to tackle some of the world's toughest problems. She oversaw the day-to-day operations for the Elders.

Mabel Wisse Smit and Prince Friso of Orange-Nassau married in Delft on 24 April 2004. The couple has two daughters:

After announcing the engagement of Prince Friso with Mabel in June 2003, Prime Minister Jan Peter Balkenende wrote in a letter to parliament that Mabel Wisse Smit had given "incomplete and incorrect information" about the duration and extent of her contacts with known drug lord, Klaas Bruinsma, and that because of this, the government had decided not to seek permission for the marriage from parliament. In a letter to the Prime Minister dated 9 October, Prince Friso stated that the couple had given some incomplete information, but had not given any incorrect information nor did they lie. The couple admitted that the sailing friendship with Bruinsma was indeed closer than had been mentioned, but denied a love or sexual relationship. This was later repeated by Wisse Smit in a number of interviews.

During her university years, she showed special interest in human rights situations around the world, and later specialised in Balkan diplomacy and international relations. In 1995 she was present at the peace conference in Dayton, Ohio.

In 1995 she was one of the co-founders of War Child Netherlands, she was on the Trustee Board until 1999. In 1997, she was appointed director of EU affairs of the Open Society Institute in Brussels, one of the foundations of Hungarian-American philanthropist George Soros. From 2002 to 2008, Princess Mabel worked in the London branch of the Open Society Institute where she was the International Advocacy Director, to help coordinate all international OSI advocacy activities aimed at international policy change.

Wisse Smit was co-founder of the European Action Council for Peace in the Balkans in 1994, which was a non-governmental organisation that strove for peace, democracy and stability in the Balkans, and had Margaret Thatcher, Simon Wiesenthal and Valéry Giscard d'Estaing among its members.

She studied economics and political science at the University of Amsterdam, graduating summa cum laude in 1993. During her studies she also completed internships at the United Nations, Shell, ABN AMRO and the Ministry of Foreign Affairs. In addition to Dutch, she speaks fluent English, Spanish and French.

In a report later issued by the Stichting Nederlandse Nieuwsmonitor (Dutch News Monitor Foundation), it was alleged that the Dutch media had contributed to blowing things out of proportion after the prime minister made 'unnuanced' comments during two news conferences. In this period Wisse Smit also received negative publicity by revelations about her affair, which started circa 1993, with married Bosnian UN Ambassador Muhamed Sacirbey.

Princess Mabel of Orange-Nassau (Dutch: Prinses Mabel van Oranje-Nassau; formerly Mabel Martine Wisse Smit, born Mabel Martine Los, 11 August 1968) is the widow of Prince Friso and sister-in-law of King Willem-Alexander of the Netherlands. She is a prominent human rights activist, widely known for her roles in co-founding War Child Netherlands, the European Council on Foreign Relations, Girls Not Brides: The Global Partnership to End Child Marriage, and for having served as the first Chief Executive Officer of The Elders, a grouping founded by Nelson Mandela and chaired by Kofi Annan. In 2005, the World Economic Forum recognised her as a Young Global Leader. Van Oranje is an advisor to several non-profits, including the Coalition for the International Criminal Court, the Malala Fund, Crisis Action and the Open Society Foundations.

She was born Mabel Martine Los in Pijnacker, the Netherlands. Her parents were Hendrik Cornelis "Henk" Los (27 April 1944 – 18 February 1978) and his wife Florence Malde Gijsberdina "Flos" Kooman (b. 1944) (the daughter of Anthonie Kooman (15 June 1915 – 8 November 1979) and his wife Antoinette Petronella van Woerkom). After Mabel's father died, when she was 9 years old, her mother married in 1984 Peter Wisse Smit (15 October 1939 – 11 November 2000), a Rabobank executive, and Mabel and her sister took their stepfather's surname. Princess Mabel has two younger sisters, Nicoline Los, later Nicoline Wisse Smit (b. 1970) and Eveline Wisse Smit (b. 1982). She grew up in Het Gooi in the central Netherlands.