Seth MacFarlane

In 2020, MacFarlane signed an exclusive $200 million deal with NBCUniversal. Under the deal, he will develop television projects for both internal and external networks, including the company’s upcoming new streaming service Peacock. MacFarlane, however, will still be free to shop film projects to other studios while his current shows Family Guy, American Dad!, and The Orville will continue to air on their respective networks.

MacFarlane released his fifth studio album, Once in a While on April 19, 2019. It was announced that MacFarlane would work with Andrew Cottee as the composer and arranger instead of Joel McNeely. However, he was still involved as a producer for the album.

He has received numerous awards from other organizations, including the Annie Award for Best Voice Acting in an Animated Television Production and the Saturn Award for Best Television Presentation for the Family Guy episode titled "Blue Harvest", the MTV Movie Award for Best On-Screen Duo and the Empire Award for Best Comedy for Ted. In 2019, MacFarlane received a star on the Hollywood Walk of Fame at 6259 Hollywood Blvd.

In 2018, it was announced that MacFarlane would be adapting Clive Barker’s novel Books of Blood into a feature film for Hulu. Brannon Braga would write and direct the film while MacFarlane will serve as an executive producer.

The series premiered during the 2017–2018 season, on Sunday, September 10, 2017.

MacFarlane released his fourth studio album, In Full Swing on September 15, 2017. On May 23, 2016, MacFarlane announced on his Twitter account that he was recording songs for his new album. On May 28, 2016, he revealed that the songs composed for the album were composed by Joel McNeely, whom he had worked with on the previous three albums. On May 30, 2016, MacFarlane revealed that it was his final day of recording at Abbey Road Studios and thanked all the musicians who collaborated with him on the album. The album's first lead single, "That Face", was released on August 17, 2017. The album's second single, "Almost Like Being in Love", was released on August 28, 2017. The album's third and final single, "Have You Met Miss Jones?", was released on September 7, 2017. The album received positive reviews and was nominated for two Grammy Awards for Best Traditional Pop Vocal Album and Best Arrangement, Instrumental and Vocals.

On May 4, 2016, FOX picked up a sci-fi comedy-drama series called The Orville. The show is created, executive-produced, and starred in by MacFarlane. The show is set 400 years in the future aboard the Orville, a not-so-top-of-the-line exploratory ship in the Union interstellar fleet.

Ted tells the story of John Bennett (Mark Wahlberg) and his talking teddy bear (MacFarlane) who keeps John and his girlfriend Lori Collins (Mila Kunis) from moving on with their lives. The film received generally favorable reviews from both critics and audiences, and was a box office success, opening with the highest weekend gross of all time for an original R-rated comedy. Internationally, the movie is currently the highest-grossing original R-rated comedy of all time, beating The Hangover. A sequel, Ted 2, was released on June 26, 2015.

MacFarlane released his third studio album on September 30, 2015. Titled No One Ever Tells You, it received mostly positive reviews, and earned MacFarlane a Grammy Award nomination for Best Traditional Pop Vocal Album. Due to the success of his musical endeavors, MacFarlane was honored by Barbara Sinatra at the 28th annual Frank Sinatra Celebrity Invitational on February 20, 2016. Later on in the year, MacFarlane recorded the song "Pure Imagination" as a duet with Barbra Streisand for her album Encore: Movie Partners Sing Broadway, released in August 2016.

In 2015, MacFarlane revealed support for Bernie Sanders in the 2016 U.S. presidential election, and he introduced Sanders onstage at a Los Angeles rally. After the primaries, MacFarlane then supported Hillary Clinton for president during the general election. In 2019, MacFarlane revealed support for Pete Buttigieg in the 2020 U.S. Presidential Election.

MacFarlane has a second long-running, successful adult animated series in American Dad! which has been in production since early 2005. To date, American Dad! is MacFarlane's only animated series never to have suffered an official cancellation, though it did undergo a network relocation from Fox to TBS on October 20, 2014, following the show's 11th season. TBS announced on July 16, 2013, that they had picked up the series for a 15-episode 12th season. Reportedly, the purpose of the network relocation was originally to make room for new animated broadcasts on Fox's now-defunct "Animation Domination" lineup. It was reported that the relocation of American Dad! allowed room for other shows, such as Mulaney and another animated series from Seth MacFarlane called Bordertown. Bordertown ran during the 2015–16 television season.

In 2014, MacFarlane executive-produced a two-season, 20-episode series called Blunt Talk for Starz. The series followed an English newscaster who moves to Los Angeles with his alcoholic manservant and the baggage of several failed marriages to host a sanctimonious talk show.

On October 29, 2014, it was announced that MacFarlane would host the Breakthrough Prize ceremony. The event was held on Silicon Valley and televised on November 15, 2014 on Discovery Channel and Science, and globally on November 22, 2014 on BBC World News. He returned to host the following year.

On January 27, 2014, MacFarlane announced that he wrote a companion novel based on the film's script, which was released on March 4, 2014. An audio-book version was also made available, narrated by Jonathan Frakes. MacFarlane wrote the book on weekends during shooting for the film, partially due to boredom.

MacFarlane was featured on Calabria Foti's 2013 single "Let's Fall in Love". In September 2013, it was announced that MacFarlane was working on a Christmas album scheduled for release in 2014. The album, which contains collaborations with Norah Jones and Sara Bareilles, is titled Holiday for Swing, and was released on September 30, 2014. The album was recorded between Christmas Day and New Year's Eve 2013 in Los Angeles and in studio 2 at Abbey Road Studios in London. The album received mostly positive reviews.

However, MacFarlane was criticized for his portrayal of transsexualism in the Family Guy episode "Quagmire's Dad". Gay novelist Brent Hartinger found the episode's inclusion of transphobic remarks from Peter and Lois Griffin—as well as a scene of Brian vomiting profusely upon discovering his new girlfriend to be Glenn Quagmire's father—to be "shockingly insensitive". Hartinger continued, "Frankly, it's literally impossible for me to reconcile last night's episode with MacFarlane's words, unless I come to the conclusion that the man is pretty much a complete idiot". The Gay and Lesbian Alliance Against Defamation, a LGBT media watchdog organization, shared "serious concerns being voiced from members of the community" about the episode. MacFarlane said he was "surprised" by the negative reaction to "Quagmire's Dad", saying that "it seemed that [gay commentators] were not picking up on the fact that it was a very sympathetic portrayal of a transsexual character". He further added, "Look, Brian happens to be a heterosexual character, as I am. If I found out that I had slept with a transsexual, I might throw up in the same way that a gay guy looks at a vagina and goes, 'Oh, my God, that's disgusting.'"

On July 16, 2014, MacFarlane was served with a lawsuit from the production company of a series of Internet videos called Charlie the Abusive Teddy Bear claiming that Ted infringes on the copyright of its videos due to the Ted bear largely matching the background story, persona, voice tone, attitude, and dialogue of the Charlie bear. The suit was dismissed with prejudice on March 23, 2015, after the plaintiffs conceded Ted was independently created and withdrew the suit.

After six months, MacFarlane returned to Fox with a "very, very simply, crudely animated film – with just enough to get the tone of the show across" to present to the executives, who loved the pilot and ordered the series immediately. In July 1998, Fox announced the purchase of Family Guy for a January 1999 debut. Family Guy was originally intended to be a series of shorts on MADtv, much in the same way The Simpsons had begun on The Tracey Ullman Show a decade earlier. Negotiations for the show's MADtv connection fell through early on as a result of budgetary concerns. At age 24, MacFarlane was television's youngest executive producer.

While MacFarlane regularly does extensive voice acting work for American Dad!, he has left much of the show's creative direction up to Weitzman and Barker. MacFarlane has credited this move with helping to give the series its own distinct voice and identity. Though, as announced on November 4, 2013, Barker departed American Dad! after 10 seasons of serving as the show's producer/co-showrunner, resulting from creative differences as production for season 11 on TBS commenced.

In 2013 and 2014, MacFarlane produced one season of a live-action sitcom called Dads. The series, revolves around Eli, played by Seth Green, and Warner, played by Giovanni Ribisi, two successful guys in their 30s whose world is turned upside down when their dads move in with them. MacFarlane, Alec Sulkin and Wellesley Wild executive-produced the series, with Sulkin and Wild writing.

Other than Family Guy and American Dad!, MacFarlane voices characters in other cartoon shows and films. He voiced Wayne "The Brain" McClain in an episode of Aqua Teen Hunger Force. He has also voiced various characters on Adult Swim's Robot Chicken, including a parody of Lion-O and Emperor Palpatine as well as Peter Griffin in the Season 2 premiere – he even parodied himself in the Season 4 premiere, in which he renewed the show simply by mentioning it in a Family Guy-like cutaway after its fictitious cancellation at the end of Season 3. He also played the villain "The Manotaur" in Bob Boyle's animated kids series Yin Yang Yo!. In addition, MacFarlane voiced Johann Kraus in the 2008 film Hellboy II: The Golden Army. He also had a guest appearance in the animated film Futurama: Into the Wild Green Yonder where he sings "That Was Then (And This is Too)", the opening theme. He had also starred in a commercial for Hulu in which he plays an alien presenting Hulu as an "evil plot to destroy the world", progressively as his famous Family Guy and American Dad! characters. He also lent his voice to the series finale movie of the Comedy Central series, Drawn Together.

On October 1, 2012, it was announced that MacFarlane would host the 85th Academy Awards on February 24, 2013. He also presented the nominees with actress Emma Stone, on January 10, 2013. In addition to hosting, MacFarlane was also nominated in the Academy Award for Best Original Song category for co-writing the theme song "Everybody Needs a Best Friend" for his film Ted with Walter Murphy. Critical response to MacFarlane's performance was mixed. Columnist Owen Gleiberman of Entertainment Weekly commented "By calling constant attention to the naughty factor," MacFarlane created "an echo chamber of outrage, working a little too hard to top himself with faux-scandalous gags about race, Jews in Hollywood, and the killing of Abraham Lincoln." Tim Goodman of The Hollywood Reporter praised MacFarlane's performance saying that he did "impressively better than one would have wagered." He also noted that he added "plenty of niceties with a little bit of the Ricky Gervais bite-the-hand-that-feeds-you thing and worked the juxtaposition rather nicely." He stirred up controversy in the form of a musical number titled "We Saw Your Boobs".

MacFarlane played Ziggy in the 2010 film Tooth Fairy. In August 2010, he appeared as a guest voice-over in a sci-fi themed episode of Disney's Phineas and Ferb entitled "Nerds of a Feather". On September 15, 2012, MacFarlane hosted the season premiere of Saturday Night Live, with musical guest Frank Ocean. The episode was MacFarlane's first appearance on the show. MacFarlane had a cameo in the 2013 film Movie 43. MacFarlane collaborated with Matt Groening on an episode of The Simpsons and Futurama. In 2016, he had a voice role in the animated film Sing, as well as serving as a major performer on the film's soundtrack. In 2017, he appeared in Steven Soderbergh's heist comedy Logan Lucky, alongside Channing Tatum and Adam Driver. In 2019, MacFarlane appeared in the Showtime limited series The Loudest Voice.

From 2012 until 2013, MacFarlane was in a relationship with Emilia Clarke. They have remained on good terms.

MacFarlane has performed as a singer at Carnegie Hall in New York and the Royal Albert Hall in London. He has released five studio albums, in the same vein of his musical idol Frank Sinatra, beginning with Music Is Better Than Words in 2011. He has been nominated for five Grammy Awards for his musical work. He hosted the 85th Academy Awards in 2013 and was also nominated for Best Original Song for the song "Everybody Needs a Best Friend" from Ted.

During his childhood, MacFarlane developed an interest in illustration and began drawing cartoon characters Fred Flintstone and Woody Woodpecker, as early as two years old. By the age of five, MacFarlane knew that he would want to pursue a career in animation, and began by creating flip books, after his parents found a book on the subject for him. Four years later, aged nine, MacFarlane began publishing a weekly comic strip titled "Walter Crouton" for The Kent Good Times Dispatch, the local newspaper in Kent, Connecticut, which paid him five dollars per week. In one anecdote from the time, MacFarlane said in an October 2011 interview that as a child he was always "weirdly fascinated by the Communion ceremony". He created a strip with a character kneeling at the altar taking Communion and asking "Can I have fries with that?" The paper printed it and he got an "angry letter" from the local priest; it led to "sort of a little mini-controversy" in the town.

In August 2011, Fox ordered a 13-part updated series of Cosmos: A Spacetime Odyssey. MacFarlane co-produced the series with Ann Druyan and Steven Soter. The new series is hosted by Neil deGrasse Tyson and began airing on the channel in March 2014, with repeats airing on the National Geographic Channel on the next night. In addition to serving as one of the executive producers, MacFarlane provided voices for characters during the animated portions of the series.

MacFarlane made his directorial live-action film debut with the release of Ted in 2012. He announced that he was directing it on an episode of Conan that aired on February 10, 2011. Along with directing the film, he also wrote the screenplay, served as producer, and starred as the title character.

He signed a record deal with Universal Republic Records and released a big band/standards album in 2011. MacFarlane's debut studio album, Music Is Better Than Words, was released on September 27, 2011, drawing on his training in and attraction to "the Great American Songbook and particularly the early- to late-'50s era of orchestration". The singer, asked about his experience with the music, said he did "old Nelson Riddle, Billy May charts [with] one of my composers, Ron Jones, [who] has a group called the Influence Jazz Orchestra that he performs with throughout L.A." His album was nominated in the Best Traditional Pop Vocal Album category at the 54th Grammy Awards. Music Is Better Than Words received a score of 52 out of 100 on Metacritic's compilation of music critic reviews.

In May 2011, it was announced that MacFarlane would be reviving The Flintstones for the Fox network, with the first episode airing in 2013. MacFarlane said that he would provide the voice of Barney Rubble. In October 2011, MacFarlane was working on another animated series with Alex Borstein and Gary Janetti. In 2015, MacFarlane was developing sitcom called 2 Black Dudes with J. Lee and Mark Mariano. All three series′ did not move forward with an order by the network.

MacFarlane told The Hollywood Reporter, "If I did a Broadway musical, I'd probably want to do something a little bit more old-fashioned...I wouldn't necessarily do something that was as edgy as what they [Matt Stone and Trey Parker] have done. The challenge to me would be more along the lines of, gosh, can somebody write Oklahoma! for 2011?" He has also said that, "The good thing about Broadway is that you don't have to worry about an airdate. It gets done when it gets done."

MacFarlane, in recognition of "his active, passionate commitment to humanist values, and his fearless support of equal marriage rights and other social justice issues", was named the Harvard Humanist of the Year in 2011.

MacFarlane often participates as one of the "roasters" in the annual Comedy Central Roasts. MacFarlane is the only person to serve as roastmaster for more than one Comedy Central roast. In 2010, he filled this role for The Comedy Central Roast of David Hasselhoff. The following year he was roastmaster of Comedy Central roasts of Donald Trump and Charlie Sheen.

On July 16, 2010, MacFarlane's mother, Ann Perry Sager, died from cancer. Her death was reported by Larry King on his show Larry King Live, who acknowledged a conversation he had with her during an interview with her son in May 2010.

MacFarlane developed a Family Guy spin-off called The Cleveland Show, which focuses on the character of Cleveland Brown and his family. The idea for the show originated from a suggestion by Family Guy writer and voice of Cleveland, Mike Henry. Fox ordered 22 episodes and the series first aired on September 27, 2009. The show, which was picked up to air a first season consisting of 22 episodes, was picked up by Fox for a second season, consisting of 13 episodes, bringing the total number to 35 episodes. The announcement was made on May 3, 2009 before the first season even premiered. Due to strong ratings, Fox picked up the back nine episodes of season 2, making a 22-episode season and bringing the total episode count of the show to 44. The series ended on May 19, 2013, with a total of 4 seasons and 88 episodes, and the character of Cleveland returned to Family Guy in the episode He's Bla-ack!. This is the only animated series created by MacFarlane that does not have him voicing the main character.

In 2009, MacFarlane began work on the animated series Bordertown. The series is set in Texas and follows a border patrol agent and a Mexican immigrant, satirizing America's changing cultural landscape. It ran for 13 episodes in the first half of 2016, on Fox.

MacFarlane has a baritone voice. He is a pianist and singer who, in his early years, trained with Lee and Sally Sweetland, the vocal coaches of Barbra Streisand and Frank Sinatra. In an interview with NPR, MacFarlane commented on their vocal training, to which he said "They really drill you," he said. "They teach you the old-style way of singing, back when you had no electronic help. ... [They teach you to] show your teeth. If you look at old photos of Sinatra while he's singing, there's a lot of very exposed teeth. That was something that Lee Sweetland hit on day in and day out, and correctly so, because it just brightens the whole performance." In 2009, he appeared as a vocalist at the BBC Proms with the John Wilson Orchestra in Prom 22 A Celebration of Classic MGM Film Musicals. In 2010, he reappeared at the Proms with the John Wilson Orchestra in a Christmas concert special. In 2012, it was announced he would again appear at the Proms with the John Wilson Orchestra in a concert celebrating Broadway musicals. In 2015, MacFarlane again appeared at The Proms as a vocalist with the John Wilson Orchestra, this time in a Sinatra program. Regarding his musical passion, MacFarlane has said, "I love and am fascinated by exciting orchestration—what you can do with a band that size—and I think in many ways it's a lost art." His music is predominantly vocal jazz, show tunes, and swing. He will occasionally use musical comedy for either his shows or movies.

MacFarlane is a graduate of the Rhode Island School of Design, where he studied animation. Recruited to Hollywood, he was an animator and writer for Hanna-Barbera for several television series, including Johnny Bravo, Cow and Chicken, Dexter's Laboratory, I Am Weasel, and Larry & Steve. He made several guest appearances on TV series such as Gilmore Girls, The War at Home, Star Trek: Enterprise, and FlashForward. In 2008, he created his own YouTube series titled Seth MacFarlane's Cavalcade of Cartoon Comedy. He won several awards for his work on Family Guy, including five Primetime Emmy Awards and an Annie Award. In 2009, he won the Webby Award for Film & Video Person of the Year. He occasionally speaks at universities and colleges throughout the United States, and is an active supporter of gay rights.

During the sixth season, episodes of Family Guy and American Dad! were delayed from regular broadcast due to the 2007–2008 Writers Guild of America strike (which MacFarlane participated in to support the writers while Fox aired three Family Guy episodes without MacFarlane's permission). On February 12, 2008, the strike ended, and the series resumed airing regularly, beginning with "Back to the Woods".

On September 10, 2008, MacFarlane released a series of webisodes known as Seth MacFarlane's Cavalcade of Cartoon Comedy with its animated shorts sponsored by Burger King and released weekly.

MacFarlane is a supporter of the Democratic Party. He has donated over US$200,000 to various Democratic congressional committees and to the 2008 presidential campaign of then-U.S. Senator Barack Obama. He has stated that he supports the legalization of cannabis. MacFarlane serves on the board of directors of People for the American Way, a progressive advocacy organization.

MacFarlane has been outspoken about his support for gay rights. In 2008, prior to the holding of the U.S. Supreme Court in Obergefell v. Hodges, MacFarlane called "infuriating and idiotic" that two gay partners "have to go through this fucking dog and pony act when they stop at a hotel and the guy behind the counter says, 'You want one room or two?'" He went on to say, "I'm incredibly passionate about my support for the gay community and what they're dealing with at this current point in time".

During the 2007–08 Writers Guild of America strike, MacFarlane publicly sided with the Writers Guild, and fully participated in the strike. Official production of Family Guy was halted for most of December 2007 and various periods afterwards. Fox continued producing episodes without MacFarlane's final approval, and although he refused to work on the show during the strike, his contract with Fox required him to contribute to any episodes it subsequently produced. Rumors of continued production on Family Guy prompted the statement from MacFarlane that ".....it would just be a colossal dick move if they did that". During the strike, MacFarlane wrote an inside joke into an episode of Family Guy about Jon Stewart's choice to return to the air and undermine the writers of The Daily Show, causing Stewart to respond with an hour-long call in which he questioned how MacFarlane could consider himself the "moral arbiter" of Hollywood. The strike ended on February 12, 2008.

On July 22, 2007, in an interview with The Hollywood Reporter, MacFarlane announced that he may start working on a feature film, although "nothing's official". In September 2007, Ricky Blitt gave TV.com an interview confirming that he had already started working on the script. Then in TV Week on July 18, 2008, MacFarlane confirmed plans to produce a theatrically released Family Guy feature film sometime "within the next year". He came up with an idea for the story, "something that you could not do on the show, which [to him] is the only reason to do a movie". He later went on to say he imagines the film to be "an old-style musical with dialogue" similar to The Sound of Music, saying that he would "really be trying to capture, musically, that feel". On October 13, 2011, MacFarlane confirmed that a deal for a Family Guy film had been made, and that it would be written by himself and series co-producer Ricky Blitt. On November 30, 2012, MacFarlane confirmed plans to produce a Family Guy film.

MacFarlane was the executive producer of a live-action sitcom starring Rob Corddry called The Winner. The plot has a man named Glen discussing the time he matured at 32 and has him pursuing his only love after she moves in next door. Glen meets her son and both become good friends. The show ran on Fox for six episodes in Spring 2007.

On October 3, 2007, Bourne Co. Music Publishers filed a lawsuit accusing Family Guy of infringing its copyright on the song "When You Wish Upon a Star", through a parody song titled "I Need a Jew" appearing in the episode "When You Wish Upon a Weinstein". Bourne Co., which holds the copyright, alleged the parody pairs a "thinly veiled" copy of their music with antisemitic lyrics. Named in the suit were MacFarlane, 20th Century Fox Film Corp., Fox Broadcasting Co., Cartoon Network, and Walter Murphy; the suit sought to stop the program's distribution and asked for unspecified damages. Bourne argued that "I Need a Jew" uses the copyrighted melody of "When You Wish Upon a Star" without commenting on that song, and that it was therefore not a First Amendment-protected parody per the ruling in Campbell v. Acuff-Rose Music, Inc. On March 16, 2009, United States District Judge Deborah Batts held that Family Guy did not infringe on Bourne's copyright when it transformed the song for comical use in an episode.

In December 2007, Family Guy was again accused of copyright infringement when actor Art Metrano filed a lawsuit regarding a scene in Stewie Griffin: The Untold Story, in which Jesus performs Metrano's signature magic parody act, involving absurd faux magical hand gestures while humming the distinctive tune "Fine and Dandy". MacFarlane, 20th Century Fox, Steve Callaghan, and Alex Borstein were all named in the suit. In July 2009, a federal district court judge rejected Fox's motion to dismiss, saying that the first three fair use factors involved—"purpose and character of the use", "nature of the infringed work", and "amount and substantiality of the taking"—counted in Metrano's favor, while the fourth—"economic impact"—had to await more fact-finding. In denying the dismissal, the court held that the reference in the scene made light of Jesus and his followers—not Metrano or his act. The case was settled out of court in 2010 with undisclosed terms.

In addition, a Family Guy video game was released in 2006. Two years later, in August 2007, he closed a digital content production deal with AdSense. MacFarlane takes cast members on the road to voice characters in front of live audiences. Family Guy Live provides fans with the opportunity to hear future scripts. In mid-2007, Chicago fans had the opportunity to hear the then upcoming sixth-season premiere "Blue Harvest". Shows have been played in Montreal, New York City, Chicago, and Los Angeles.

MacFarlane has appeared in sitcoms, comedy and news programs, independent films, and other animated shows. In 2002, MacFarlane appeared in the Gilmore Girls episode "Lorelai's Graduation Day". Four years later on November 5, 2006, MacFarlane guest starred on Fox's The War at Home as "Hillary's Date", an unnamed 33-year-old man who secretly dates teenaged Hillary in the episode "I Wash My Hands of You". MacFarlane also appeared as the engineer Ensign Rivers on Star Trek: Enterprise in the third-season episode "The Forgotten" and the fourth-season episode "Affliction". During 2006, MacFarlane had a role in the independent film Life is Short. He portrayed Dr. Ned, a psychologist who advises a short man (played by Freaks and Geeks star Samm Levine) to have relationships with taller women. He is a frequent guest on the radio talkshow Loveline, hosted by Dr. Drew Pinsky.

MacFarlane appeared on the November 11, 2006 episode of Fox's comedy show MADtv and performed a live action re-enactment of a scene from the Family Guy episode "Fast Times at Buddy Cianci Jr. High". In the scene, Peter and Lois suspect Chris of murdering his teacher's husband. As a reaction, a terrified Meg jumps out the window. For the live-action sequence, besides MacFarlane, Nicole Parker played Lois, Ike Barinholtz played Chris, Nicole Randall Johnson played Meg, and Keegan-Michael Key played Stewie. According to MacFarlane, the live-action thing didn't work too well. After that clip, MacFarlane showed the same scene, but with celebrities who didn't pay attention to the script. They messed up their lines so badly that MacFarlane, in his Peter voice, screamed "The script, guys! Come on!" MacFarlane served as a host to the Canadian Awards for the Electronic & Animated Arts's Second Annual Elan Awards on February 15, 2008. MacFarlane has also appeared on news shows and late night television shows such as Jimmy Kimmel Live! and Late Show with David Letterman. Three months later on March 24, 2007, MacFarlane was interviewed on Fox's Talkshow with Spike Feresten, and closed the show by singing the Frank Sinatra song "You Make Me Feel So Young". He also provided Stewie's voice when he appeared as a brain tumor-induced hallucination to Seeley Booth in an episode of Bones, writing his own dialogue for the episode. On May 8, 2009, MacFarlane was a guest on Real Time with Bill Maher.

MacFarlane is a frequent speaking guest on college campuses. On April 16, 2006, he was invited by Stanford University's ASSU Speakers' Bureau to address an audience of over 1,000 at Memorial Auditorium. MacFarlane was invited by Harvard University's class of 2006 to deliver the "class day" address on June 7, 2006. He spoke as himself, and also as Peter Griffin, Stewie Griffin and Glenn Quagmire. He also has delivered speeches at George Washington University, Washington University in St. Louis, the University of Texas at Austin, the University of Missouri, University of Toledo, Bowling Green State University, and Loyola Marymount University.

MacFarlane's success with Family Guy has opened doors to other ventures relating to the show. On April 26, 2005, he and composer Walter Murphy created Family Guy: Live in Vegas. The soundtrack features a Broadway show tune theme, and MacFarlane voiced Stewie in the track "Stewie's Sexy Party". A fan of Broadway musicals, MacFarlane comments on using musicals as a component to Family Guy:

American Dad! was first shown after Super Bowl XXXIX, debuting with the episode "Pilot", which MacFarlane co-wrote. This February 6, 2005 series premiere was somewhat of an early sneak preview as the program would not begin airing regularly as part of Fox's Animation Domination until May 1, 2005. Because of atypical scheduling of the show's first 7 episodes, American Dad! has a controversial season number discrepancy in which many are divided as to how many seasons the program has had. Beyond division between media journalists and fans, there has been conflicting reports as to what season the show is in even between American Dad! creators and the show's official website—both from its original Fox website and now from TBS website. At Comic-Con 2013 on July 20, American Dad! co-creator Mike Barker hinted that an American Dad! movie—centering on the Roger character and set from his birth planet—is in the works and partially written. What with Barker's departure from the series however, it is unclear if any of these plans have been scrapped or modified in any way.

In a 2004 interview with The Daily Princetonian, MacFarlane noted his similarities to Brian Griffin from Family Guy, revealing: "I have some Brian type issues from time to time—looking for the right person—but I date as much as the next guy."

On the morning of September 11, 2001, MacFarlane was scheduled to return to Los Angeles on American Airlines Flight 11 from Boston. Suffering from a hangover after the previous night's celebrations that followed his speech at his alma mater, the Rhode Island School of Design, and with an incorrect departure time (8:15 a.m. instead of 7:45 a.m.) from his travel agent, he arrived at Logan International Airport about ten minutes too late to board the flight, as the gates had been closed. Fifteen minutes after departure, American Airlines Flight 11 was hijacked, and at 8:46 a.m. it was flown into the North Tower of the World Trade Center, killing everyone on board. MacFarlane said:

MacFarlane has been nominated for twenty-three Primetime Emmy Awards for his work on Family Guy and has won five times, in 2000, 2002, 2016, 2017 and 2019. He has been nominated for five Grammy Awards for his work in Family Guy: Live in Vegas, Music Is Better Than Words, Family Guy, No One Ever Tells You, and In Full Swing. He was nominated for an Academy Award for Best Original Song for co-writing the opening song, "Everybody Needs a Best Friend", from his film Ted with the film's composer Walter Murphy.

Family Guy first aired January 31, 1999. MacFarlane's work in animating Family Guy has been influenced by Jackie Gleason and Hanna-Barbera along with examples from The Simpsons and All in the Family. In addition to writing three episodes, "Death Has a Shadow", "Family Guy Viewer Mail 1" and "North by North Quahog", MacFarlane voices Family Guy' s main male characters – Peter Griffin, Stewie Griffin, Brian Griffin, and Glenn Quagmire as well as Tom Tucker, his son Jake Tucker, and additional characters. Bolstered by high DVD sales and established fan loyalty, Family Guy developed into a US$1-billion franchise. On May 4, 2008, after approximately two and a half years of negotiations, MacFarlane reached a US$100-million agreement with Fox to keep Family Guy and American Dad! until 2012. The agreement makes him the world's highest paid television writer.

Although MacFarlane enjoyed working at Hanna-Barbera, he felt his real calling was for prime-time animation, which would allow a much edgier style of humor. He first pitched Family Guy to Fox during his tenure at Hanna-Barbera. A development executive for Hanna-Barbera, who was trying to get back into the prime-time business at the time, introduced MacFarlane to Leslie Kolins and Mike Darnell, heads of the alternative comedy department at Fox. After the success of King of the Hill in 1997, MacFarlane called Kolins once more to ask about a possible second pitch for the series. Fox offered the young writer a strange deal: they gave him a budget of US$50,000 to produce a pilot that could lead to a series (most episodes of animated prime-time productions cost at least US$1 million). Recalling the experience in an interview with The New York Times, MacFarlane stated, "I spent about six months with no sleep and no life, just drawing like crazy in my kitchen and doing this pilot".

MacFarlane was recruited during the senior film festival by development executive Ellen Cockrill and President Fred Seibert. He went to work at Hanna-Barbera (then Hanna-Barbera Cartoons) based on the writing content of The Life of Larry, rather than on cartooning ability. He was one of only a few people hired by the company solely based on writing talent. He worked as an animator and writer for Cartoon Network's Cartoon Cartoons series. In 1996, MacFarlane created a sequel to The Life of Larry entitled Larry & Steve, which features a middle-aged character named Larry and an intellectual dog, Steve. The short was broadcast as one of Cartoon Network's World Premiere Toons. He described the atmosphere at Hanna-Barbera as resembling an "old-fashioned Hollywood structure, where you move from one show to another or you jump from a writing job on one show to a storyboard job on another". MacFarlane worked on four television series during his tenure at the studio: Dexter's Laboratory, Cow and Chicken, I Am Weasel, and Johnny Bravo. Working as both a writer and storyboard artist, MacFarlane spent the most time on Johnny Bravo. He found it easier to develop his own style at Johnny Bravo through the show's process of scriptwriting, which Dexter's Laboratory, Cow and Chicken, and I Am Weasel did not use. As a part of the Johnny Bravo crew, MacFarlane met actors and voiceover artists such as Adam West and Jack Sheldon of Schoolhouse Rock! fame. Meeting these individuals later became significant to the production and success of his Family Guy series.

MacFarlane received his high school diploma in 1991 from the Kent School. While there, he continued experimenting with animation, and his parents gave him an 8 mm camera. MacFarlane went on to study film, video, and animation at the Rhode Island School of Design (RISD), where he earned a Bachelor of Fine Arts degree. As a student, he had intended to work for Disney but changed his mind after graduating.

MacFarlane served as executive producer of the Neil deGrasse Tyson-hosted Cosmos: A Spacetime Odyssey, an update of the 1980s Cosmos series hosted by Carl Sagan. He was instrumental in providing funding for the series, as well as securing studio support for it from other entertainment executives.

Seth Woodbury MacFarlane (/m ə k ˈ f ɑːr l ɪ n / ; born October 26, 1973) is an American producer and director, actor, and singer, working in both animation and live-action, for television and cinema, with a focus on comedy. MacFarlane is the creator of the TV series Family Guy (1999–present) and The Orville (2017–present), and co-creator of the TV series American Dad! (2005–present) and The Cleveland Show (2009–2013). He also wrote, directed, and starred in the films Ted (2012), its sequel Ted 2 (2015), and A Million Ways to Die in the West (2014).

MacFarlane was born and raised in Kent, Connecticut. His parents, Ronald Milton MacFarlane and Ann Perry (née Sager), were born in Newburyport, Massachusetts. MacFarlane's younger sister Rachael is also a voice actress. He has roots in New England going back to the 1600s, and is a descendant of Mayflower passenger William Brewster. MacFarlane's parents met in 1970, when they both lived and worked in Boston, Massachusetts, and married later that year. The couple moved to Kent in 1972, where Ann began working in the Admissions Office at South Kent School. She later worked in the College Guidance and Admissions Offices at the Kent School, a selective college preparatory school, where Ronald was a teacher.