Wesley West

West and his wife were philanthropists giving to a variety of causes. Two of these, higher education and the arts, stand out. West gave funds to create the Neva and Wesley West Scholarship in the College of Business Administration at Sam Houston State University. Together, they gave generously to the Baylor College of Medicine in Houston notably to the Department of Ophthalmology. The Neva and Wesley West Chair in the Texas A&M Health Sciences Center, Graduate School of Biomedical Sciences, Houston, Institute of Biosciences and Technology was created to fund faculty conducting research to ultimately aid in the treatment of infectious diseases. They also gave generously to the Texas Medical Center, the largest medical center in the world, of which Neva was a lifetime Director. Upon her death in 2007, the Texas Medical Center flags were flown at half-mast for days. His wife Neva was a true patron of the arts, giving numerous donations to the Houston Grand Opera (of which she was a member of the board), the Houston Symphony, and the Houston Museum of Fine Arts (of which she was a lifetime trustee). The Houston Symphony gave a concert gala in her honor in 1993. Together, Wesley and Neva created the Neva and Wesley West Foundation, now the Stedman West Foundation, which continues their philanthropic activities. The foundation gave funds to aid in the creation of Jesus Bautista Moroles' Houston Police Officer's Memorial in 1990.

West inherited many properties and associated businesses from his father's estate, much of which he shared with his brother James Jr. Two of these were the Indio and Chupadero ranches. In 1960, West divided these ranches with James Jr.'s heirs keeping the consolidated middle sections of the properties. He named these 40,000 acres the Faith Ranch. The ranch is maintained by descendants of his daughter Betty Ann West Stedman.

He married Neva Yvonne (née Watkins) in 1930. Together, they had three children; sons Wesley (who died of leukemia at age seven) and James W., and daughter Betty Ann.

Wesley Wendell West (1906-1984) was the second son of James Marion West and younger brother of James Marion West, Jr. Like his brother and father before him, he was a noted Texas rancher, oilman, and philanthropist. He founded Wesley West Minerals, a mineral rights owning entity currently operating in Texas, Alabama, Mississippi, and New Mexico, and Wesley West Cattle L.P.